The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
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BCAAs reducing PEM

Discussion in 'Post-Exertional Malaise, Fatigue, and Crashes' started by Mary, Jan 3, 2015.

  1. Mary

    Mary Senior Member

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    In early November I came across some articles which indicated that branched chain amino acids could help reduce or even prevent PEM. I've posted links below. I had taken a 2nd look at Nutreval results from over 4 years ago, and saw my leucine was quite low, and tryptophan borderline high, which is described in one of the articles as contributing to PEM. I started taking BCAAs - the product I took also had glutamine added (http://www.iherb.com/MRM-BCAA-G-600...lc=en-US&w=mrm bcaa g 6000&rc=30&sr=null&ic=1) and within a couple of days my energy increased and then I recovered from a crash some 20 hours sooner than I typically do. I was taking 12 caps a day, divided doses, on an empty stomach. And then shortly after that started detoxing -- argggh! I finally figured out it was the glutamine (used in phase II liver detox), switched to plain BCAAs without the glutamine and the detoxing stopped. Right now I'm taking 8 capsules a day in divided doses of this: http://www.vitacost.com/optimum-nutrition-bcaa-1000-caps-1000-mg-400-capsules-3, with no bad side effects.

    I've also just started taking DMG (not TMG) and think it may be helping as well, though it's too soon to tell, will post more about the DMG after I've been on it for awhile. I'm taking 3 125 mg. DMG caps a day (Now Foods)

    http://www.ncf-net.org/forum/Fword.htm
    http://www.dynamicchiropractic.com/mpacms/dc/article.php?id=41341

    http://www.ncbi.nlm.nih.gov/pubmed/11310928
    http://jn.nutrition.org/content/136/2/544S.full
     
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  2. Gondwanaland

    Gondwanaland Senior Member

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    Very interesting, @Mary
    Unfortunately I can't supplement with aminoacids since they quickly raise my ammonia, which lowers my serotonin, and get a nasty cascade going. Just as a reminder to those dealing with high ammonia issues... Not to mention the uric acid...
     
  3. Mary

    Mary Senior Member

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    I'm sorry to hear that amino acids raise ammonia for you! This illness can get so complicated - which is why this board is so valuable - I don't think anyone could be on top of all the variables and permutations we deal with.
     
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  4. gettinbetter

    gettinbetter Senior Member

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    I bought some BCAA in a powdered form and noticed significant improvement in stamina but they caused severe kidney pain so I stopped taking it
    I would like to try them again maybe it was the brand

    I am wondering why the kidney pain?
     
  5. Mary

    Mary Senior Member

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    Are your kidneys okay? If someone has kidney disease, too much protein can be harmful because the kidneys don't filter properly. I don't know if this would apply to amino acids, which are the building blocks of protein. Although on the other hand, this article https://www.ncbi.nlm.nih.gov/pubmed/16365103 talks about using BCAAs to help when protein intake is restricted due to kidney disease.

    My guess is there may have been some sort of contaminant or filler in the bulk BCAAs you bought which hurt your kidneys. BCAAs have never bothered my kidneys. I've taken these brands with no trouble: Optimum Nutrition (capsules), Bulk Supplements (bulk form) and MRM (capsule form). And I'm prone to UTIs and kidney infections.
     
  6. gettinbetter

    gettinbetter Senior Member

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    Last edited: Aug 26, 2017
  7. Jessie 107

    Jessie 107

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    Hello,
    After
    Hello,
    After reading this post about Amnio Acids, I decided to try them.
    And I have seen a improvement with PEM, I still get it but instead of suffering it for two to three days, this is reduced to one day, the second day I still feel bad but not full PEM bad. So I will be continuing to take them.
    Thankyou for posting this information.
    Jessie
     
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  8. perrier

    perrier Senior Member

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    Which brand are you taking?
     
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