Hello everyone. I've been lurking for some time reading a lot, it's a great resource! Thanks to everyone. After the digging into the methylation problems, I have "some back-to-basics" questions. When it comes to homocysteine values I see two schools of thought. The more generic doctors don't seem overly concerned with high Hcy values, e.g. in the range of 15 - 25 pmol/L, in fact they define this range as "mild". Other doctors instead are highly concerned with any value > 9-10pmol/L and say that anything above 6-7 should be addressed. In my case I was found with 98 pmol/L back in 2011, I started supplementing with the usual methyl-B12, B complex, folic acid and in one year it came down to ~13. Problem is I seem to be stuck there, no matter how much coenzymated Bs, SAM-e, I take, the value doesn't go down any further. Questions: Is a value of 13 really that bad? I am 40, no smoking and drinking, healthy diet. Is it normal that the regular B vitamin therapy works up to a point and then stops? My ND suggested to check for mthfr mutations. I live in Italy, while I can probably find a lab near here to test that I see people here tend to use more comprehensive panels that look for many other related mutations. Can you recommend an international lab that can offer a more comprehensive test to check for methylation issues? Thanks in advance.