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Bacterial metabolic toxins: a new mechanism for lactose and food intolerance and IBS

Discussion in 'Other Health News and Research' started by Waverunner, Apr 30, 2011.

  1. Waverunner

    Waverunner Senior Member

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    This could have some huge relevance for CFS in my eyes. Does anyone have access to the full paper? Can we maybe add it to the library?

    http://www.ncbi.nlm.nih.gov/pubmed?term=20851732

    Toxicology. 2010 Dec 30;278(3):268-76. Epub 2010 Sep 18.

    "Abstract
    Lactose and food intolerance cause a wide range of gut and systemic symptoms, including gas, gut pain, diarrhoea or constipation, severe headaches, severe fatigue, loss of cognitive functions such as concentration, memory and reasoning, muscle and joint pain, heart palpitations, and a variety of allergies (Matthews and Campbell, 2000; Matthews et al., 2005; Waud et al., 2008). These can be explained by the production of toxic metabolites from gut bacteria, as a result of anaerobic digestion of carbohydrates and other foods, not absorbed in the small intestine. These metabolites include alcohols, diols such as butan 2,3 diol, ketones, acids, and aldehydes such as methylglyoxal (Campbell et al., 2005, 2009). These 'toxins' induce calcium signals in bacteria and affect their growth, thereby acting to modify the balance of microflora in the gut (Campbell et al., 2004, 2007a,b). These bacterial 'toxins' also affect signalling mechanisms in cells around the body, thereby explaining the wide range of symptoms in people with food intolerance. This new mechanism also explains the most common referral to gastroenterologists, irritable bowel syndrome (IBS), and the illness that afflicted Charles Darwin for 50 years (Campbell and Matthews, 2005a,b). We propose it will lead to a new understanding of the molecular mechanism of type 2 diabetes and some cancers.

    Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

    PMID: 20851732 [PubMed - indexed for MEDLINE]"

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