I was taking sam-e which helped me come off the effexor I was on. Then I had a split with the girl I was seeing. The split caused a massive stress response and since then I have had despair, which I have mostly managed and am seeing a yoga counsellor to process some stress. I have had a severe response to sex where I have felt like my body was ready to die - that fatigued.I couldn't even use a pair of scissors to open something due to having zero strength. If I felt so messed up after sex, might hormones be a massive contributing factor? Realistically I think the effexor suppressed my system so I used less stress hormones. Feeling so low I'm struggling to see any future improvement.