LIVER EXTRACT - PROTEIN MYSTERY FACTOR EFFECTIVENESS DUPLICATED In 1932 a Nobel Prize was awarded for recognizing that liver could amazingly cure pernicious anemia very well. Studies were done with extracts and more and more concentrated extracts over time trying to find the "protein mystery factor" as some of the authors termed it at them. They found same amazing responses. Post partum Depression was cured overnight. Hallucinating schizophrenics were able to be released from psychiatric hospitals in 3 days, a miracle in the days before Thorazine was invented. However, it wasn't suppressed as with a drug, it had gone rapidly into remission. Against pernicious anemia it was a tremendous success, not just reducing MCV but healing most all symptoms the person has, like severe fatigue, epithelial lesions, mood issues, personality issues, poor healing and all sorts of symptoms. The liver concentrate was miraculous. In 1942 the Nobel Prize was for folic acid. The 1948 Nobel Prize was for B12 (Cyanocobalamin). By 1960 it was clear that this cyanocbl was NOT contained in beef liver extract as the two active cobalamins, adenosylcbl and methylcbl were properly identified. It was also very clear that cyanocbl and folic acid did not give except most reduced and slowly, the results of protein mystery factor. Cyanocbl and folic acid, alone or in combination, relieved a few symptoms like large MCV over a multi month period. A few people started to have a noticeable response to injections of cyanocbl before leaving the doctor’s office. The official stance of the AMA was that these people were having placebo effect, rather than Protein Mystery Factor response and that they should not be given more. Basically it established that anything like cyanob12 shouldn’t produce noticeable effects and those that have them should be prevented from doing so. Talk about bringing everybody down to the lowest common denominator. Based on the circa 1960 data, if the project had been given to me to figure out, I would have abandoned cyanocbl and gone back to liver extract and worked to duplicate the liver extract effect with methylcbl and adenosylcbl as identified in 1959. It probably would have taken some years to figure out how to have those two. They are actually easier than cyanocbl because during the 50s the researchers found that if they spiked the liver extract with cyanide they could get “good” yields of the preferred “b12” instead of all those pesky analogs like adenosylcbl and methylcbl. All those pesky bacteria wanted to brew up methylcbl so they had to be spiked with cyanide to produce B12. Here they were 12 years down road from the Nobel Prize and it is now known that the Cyanocbl was an unintended lab mistake and is NOT B12 but rather an almost inactive cobalamin, one of many such, and is a “disappointment” (compared to liver extract). Instead of saying “We should try the combinations of nutrients in liver extract” they doubled down on a “disappointment”. So let’s do the Vince Lombardi thing; “Gentlemen, this is a football” as he held one up. The metaphorical football in this case is Protein Mystery Factor. Whether Rich VK knew that he was looking for Protein Mystery Factor or not, I don’t know. He was about my age and was likely exposed to many similar things growing up. Whether he knew he was looking for that or whatever would fix a “partial methylation block” he was asking a lot of the questions that need to be asked. After a year of dialog with Rich it was clear that a genetic basis that affected b12 conversion directly likely wasn’t the answer, at least not for very many people. So now, looking at liver extract we can be pretty sure that it contained methylcbl, adenosylcbl and a relatively large amount of l-methylfolate, plus lots of other vitamins and other factors, depending upon the refinement level. Let us toast the generations of Jewish and Catholic and other mothers who insisted “Eat your liver”. They kept generations healthy that might have succumbed to FMS and CFS back in the 30s and 40s and 50s. It might very well have kept me healthy except my mother hated liver and never served it. Rich’s questioning led to my re-examination of my ideas. The answer jumped out and stomped on me in the form of glutathione precursors. The trial (will be presented in a different post) induced the most overwhelmingly severe folate deficiency I had ever experienced and specifically identified folate deficiency symptoms and the realization that many are actually folate insufficiency symptoms as well as they are extremely dose responsive. The glutathione trial led to the understanding of the role that the “methyl trap” plays in all this, again independently identified and explained by Rich confirming what I was considering a possibility. With the glutathione trial I was intending to see if glutathione was the missing piece in my healing and that of others. It turned out to be a revelation. Instead of healing it gave us an experimental model for inducing acute folate deficiency symptoms and all four body and CNS b12 deficiency symptoms sets in order starting in hours as it shuts down methylation and continuing for months until actively reversed. If not discontinued and actively reversed soon enough it can cause (worsen) subacute combined degeneration, pernicious anemia, MCS, asthma, allergies, lesions all over the body. This actually allowed the description of folate deficiency and insufficiency symptoms and the ability to rate the folate insufficiency/ deficiency symptoms of Paradoxical Folate Deficiency/Insufficiency compared to the brutally complete folate deficiency produced by the “methyl trap” caused by the glutathione. So taking my own history of when various symptoms worsen as a child and teen, it wasn’t because of the cyanocbl in my diet suddenly as much as it was the folic acid that was always also there. Instead of poor b12 being my “lowest level of cause” it was Paradoxical Folate Deficiency/Insufficiency worsened by folic acid and cyanocbl which will also cause b12 deficiency symptoms because of the many biochemical deadlocks that are in the way. So now, in the 14 years since methyb12 and adneosylb12 have become commercially available at vitamin prices and the past few years the same for l-methylfolate as Metafolin, it is possible to make comparisons never before possible and to define the methylb12, adenosylb12 and l-methylfolate deficiencies specifically and individually, realizing that all 3 with l-carnitine are part of a mutual quadratic deadlock. DEADLOCKS – Pragmatically observed and mostly verified in literature 1. To convert cyanocbl to methylcbl requires an enzyme and ATP (requiring adenosylcbl and carnitine (requiring methylcbl) and a methyl group in addition to what may be needed for ATP production) and methylfolate for lengthened serum-halflife and utilization of active b12s 2. To convert hydroxycbl to methylcbl requires an enzyme and ATP (requiring adenosylcbl and carnitine (requiring methylcbl) and a methyl group in addition to what may be needed for ATP production) and methylfolate for lengthened serum-halflife and utilization of active b12s 3. To convert folic acid to folinic acid requires an enzyme and ATP (requiring adenosylcbl and carnitine (requiring methylcbl)) and methylfolate for lengthened serum-halflife and utilization of active b12s 4. To convert folinic acid to l-methylfolate requires an enzyme and ATP (requiring adenosylcbl and carnitine (requiring methylcbl)) and methylfolate for lengthened serum-halflife and utilization of active b12s 5. To convert adenosylcbl to methylcbl requires an enzyme and ATP (requiring adenosylcbl and carnitine (requiring methylcbl) and a methyl group in addition to what may be needed for ATP production) and methylfolate for lengthened serum-halflife and utilization of active b12s In other words, if a person is down to empty on the adb12, mb12, l-carnitine and l-methylfolate, and the possibility of quite a few other items at a <1% level each, the big 4, the blocked methylation doesn’t unblock and generalized healing does not start unless all needed deadlocking items are present. Single item tests will only work for a limited sample who happens to match that one specific most limiting factor. If it is an inactive limiting factor (hycbl, cyanocbl, folic or folinic acid) that requires the deadlocking active items to be present for inactive item conversion then healing does not turn on. The turn on of methylation and healing signals itself both by healing and an increased need for l-methylfolate and potassium. The hypothetical “protein mystery factor” in liver extract might have contained l-carnitine as the liver is a major carnitine synthesizer in the body. Depending upon how “purified” the liver extract is then very likely contains l-carnitine, adenosylcobalamin, methylcobalamin and l-methylfolate. In addition the extract could have contained a lot of vitamin A, C, b-complex and minerals. As the four specified items are given against the background of all usual vitamins and minerals and fatty acids those 4 items will start blocked methylation, and generalized healing, approximately 100% of the time, starting in hours, just as liver extract does. An objection of Rich’s was that huge doses of methlyb12 would “force methylation” and other dire warnings and such doses were not obtainable anyway in nature. As has been demonstrated 100mcg absorbed adb12/mb12 with methylfolate and l-carnitine will turn on methylation and start generalized healing. In the increase from 100mcg daily to 10,000 mcg mixed active b12s daily both l-metafolin and potassium may need some additional titration, but usually not much as compared to what has already started. Healing increases somewhat with 100x the dose but maybe by only 50%. The large doses that are needed by me and others with low CSF/CNS levels of b12 and damged CNS and is a separate compartment and is a separate consideration and not to be confused with what heals my body and others. I started feeling the mb12 with the first few mcg entering my body via diffusion. IT IS FAST. Generalized body healing not including muscles (those needed l-carnitine and adb12) turned on in 1 hour for me on a single ENZY mb12 1mg absorbing perhaps 150mcg. This is a NORMAL biologically attainable dose if one eats liver or liver extract. This speed of activity occurred with liver extract after allowing for digestion and absorption time. So, 100mcg of absorbed mb12/adb12 or either alone could start healing depending upon lockouts. And so can amounts of l-methylfolate and l-carnitine easily available in healthy beef liver. These four items in combination can replicate the speed and effectiveness of the hypothetical “protein mystery factor” because it was actually a “protein mystery complex”. The name itself suggests the single item mentality which was exhibited by carving the ONE COMMANDMENT in stone: CYANOCOBALAMIN. It has taken 80 years (liver corrects pernicious anemia Nobel) to get to an understanding of the tremendous effectiveness of liver extract concentrate and to be able to duplicate it. Folic acid and cyanocobalamin are repeatedly “disappointments” in research. They turn out to be good reasons for not buying a pig in a poke when it comes to nutrition. CYANOCOBALAMIN, HYDROXCOBALAMIN, FOLIC ACID and for some FOLINIC ACID, were marketed as being “folate” and “b12” and it is an ongoing health disaster for millions and millions. Adele Davis’s book was titled LET’S GET WELL. Her favorite nutritional item for almost every disorder known to mankind was liver. http://en.wikipedia.org/wiki/Pig_in_a_poke “The idioms pig in a poke and sell a pup (or buy a pup) refer to a confidence trick originating in the Late Middle Ages, when meat was scarce, but cats and dogs (puppies) were not. The idiom pig in a poke can also simply refer to someone buying a low-quality pig in a bag because he or she did not carefully check what was in the bag.” It severely damaged my health that the researchers of the time didn’t go back to the basics and work to duplicate the effectiveness in all particulars of the liver extract concentrate but instead focused on “proving” that cyanocbl “worked” at microscopic levels despite being a complete failure at shear fast outright healing because it wasn’t the same as liver extract and that was KNOWN. Instead they take this pig, put a new dress on it, glue some paper wings on, paint it up with lots of lipstick and rouge and throw it out a 50 story window to prove it can fly. That of course changes nothing. It still doesn’t work but now they can prove that it does at a microscopic level so we ought to be convinced of it here on the macro level of bodies needing healing.