Or maybe liver pain, but I highly think it's pancreas. Niacin is known to make pancreatic β-cells less sensitive to serum glucose. I induced myself into a over methylation state, so I really need niacin, this is the only thing is helping me. HOWEVER, I'm VERY sensitive to niacin, I can just handle 100mg/day and not more than 3 days. My pancreas start to hurt A LOT. At first Niacin decreases my Blood glucose, then using through the day it let my BG at 105mg/dl in fasting This is the only thing that can help me but it's damaging me. I SUSPECT NIACIN CAN CAUSE SOME IMBALANCE IN ANOTHER VITAMIN THAT IS VERY IMPORTANT TO PANCREAS. SOMEBODY KNOWS HOW TO ALLEVIATE MY SYMPTOMS?