You need both B12 and methylfolate for methylation. People do get positive benefits from just B12, but you will experience better results from methylation. It might take a couple months of doing methylation before you notice improvement although some people do experience improvement at the beginning of methylation. Also, some people aren't able to tolerate a high dose of B12 and methylfolate so it would be good to start low. 200 mcg or less of methylfolate.