dbkita I definitely feel more over stimulated today than I did three days ago, and my sleep was worse again. I took no TMG yesterday, so it's probably the lingering after-effects from the 2 days prior, during which I took 650 mg each day. I am currently taking only 500 mcg of methyl B, very irregularly... sometimes only once/week, sometimes 3X/week. I do okay with the methylB as long as I do not take it every day. I do not take any form of folic acid, because I have not figured out yet which is the least problematic for me. I tried Rich's simplified methylation protocol back in 2010, (with the Yasko hydorxyB and the methylmate), but after about 6 weeks I began to feel so much worse, that I couldn't handle any more of it. The severe agitated depression was not something I was willing to endure and push through. I have been there and done that far too many times, and it always ends up being destructive to my overall health. I do not have energy for intense detox that is triggered in that process. I tend to have a lot of excito-toxicity symptoms due to a heavy metal burden that has given me long term problems with agitation and insomnia. When I do get some decent sleep, I feel like a completely different person. I can function quite well, compared to my usual wired/tired self. Awaiting 23&ME to see what's up with all the snps.