^ Glad to hear it. I'm also getting TRT (as mine was borderline), and this has made some improvements - both physically and mentally.
Re testing MTHFR; I take it I only need to test for the following: MTHFR A1298C and MTHFR C677T? Is there an idiot's guide to this?
Many of us have done the 23andMe test, because many of the other SNP (mutations) in other genes influence how we choose to go about treating it. It's US-based, but I know there are international shipping instructions. For example, there is one gene (MTRR A66G) that activates B12, and because I have the double mutation, I use it (sublingual methylB12 tablets, active form) twice a day and I feel about the same lift that you and
@redaxe described, although no permanent change. In fact the frequency of taking it seems more important than whether it's 1 mg or 5 mg. So, if you're ordering tests a la carte, the MTRR A66G would also be interesting because...
So, this is what is a mystery to me: your test results were high for "active" B12, yet, when you injected hydroxy (inactive) B12, you got results. Very bizarre. It could be that the B12 is limiting your conversion of homocysteine to methionine. People with the MTHFR C677T usually have methylfolate limiting that reaction, but it's possible people like me and maybe you have the methylfolate we need and are short on the B12, you think?
You know, there are discussions about the MMA here, but I don't know. Search on methylmalonic and see what comes up. I know it means something!
Glad to hear the TRT is helping. I'm on low dose (I'm female) because I wasn't low-T, I was no-T. Makes a huge difference in my ability to get things done, and whether I even care if I get things done.
