Hi,
I have been doing Fredd's protocol for about 45 days.
Currently I am on 4mg Methyl B12, 3 mg AdenB12, 1.2mg Methylfolate, 500 LCF.
Each time I start one a dont notice any difference at all. I thought I did at first with MethylB12 but not sure now. I have tried twice a dose of 30 mg Methylb12 (enzym) with no noticeable effect.
I also take Lithium Oretate, Alpha Lipoic Acid, Benfotiamine, Magnesium Malate... plus B complex, C, Omega 3, D, Evening Primrose Oil... and Potassium
This makes me believe that maybe my issues are something else.
I was diagnosed with ME 15 years ago. i had a prolonged period of stress which gave me additional fatigue and new symptoms of constant tingling in feet, hands, face, cold hands and feet.... I had B12 serum level of 333, with an MCV which increased in a month from 100 to 103.
Because of these symptoms, lowish B12, high MCV as well as slightly raised MCH, I started Fredd's B12 protocol....
For me, taking these supplements is expensive and I have to constantly work out whether I can afford it all.. or what to do next...
I think my symptoms are worse. More anxious.. more tingling.. but I also have some real things to deal wtih.. so not sure what cause what...
Im just confused generally and not sure what to do next... I cant discern any change when I take supplements... i have always been the wired but tired type
Hi Stillgoing,
Many people have one episode of startup and settle into equilibrium, A Dose of 1-5mg each of MeCbl and AdoCbl is quite enough as a background with the methylfolate. The next part of the deadlock to add is L-carnitine fumarate, and if that doesn't ALCAR needs to be tried. After than the next most likely things, keeping everything else going and add, SAM-e, then Alpha Lipoic acid, then D-ribose, then biotin, zinc, vit D. It is assumed you are already taking A, b-complex (low dose), C, 3000iu D, E, magnesium, zinc in a multi-mineral.
The 3mg AdoCbl indicates to me likely using the Country Life Dibencozide with folic acid. If you have paradoxical folate deficiency that could be blocking you. Try Anabol Naturals Dibencoplex. Enzymatic Therapy B12 Infusion is the only 5 star MeCbl brand I currently know of for reliable results kept in place for 45-120 minutes. Below is the checklist for most of the reasons b12 therapies don't work. These are very exacting. It can fail 100% for each of the reasons.
THE 95% REASONS B12 AND FOLATE THERAPIES FAIL
Version 2.0 - 03/10/11, Version 2.1 - 05/08/11. Version 3.0 – 10/25/2012, Version 3.1 10/26/2012, Version 11/05/2012 3.2
1) They take an inactive b12, either cyanob12 or hydroxyb12. The research validating their use was primarily for reducing blood cell size in Pernicious Anemia, keeping the serum b12 level over 300pg/ml at the end of the period between injections. They make a statistically significant effect that can be seen in lab tests in a significant percentage of people compared to placebo. They do not heal most damage done by active b12 deficiencies and have little or no effect on the vast majority of symptoms. They may even block active b12 from receptor sites hindering the
effects of real b12. They both cause a keyhole effect of having only a very limited amount (estimated at 10-30mcg/day) that can actually be bound and converted to active forms. They in no way increase the level of unbound active cobalamins which appear required for most healing. They do nothing beneficial in a substantial percentage of people (20-40%) while giving the illusion that the problem is being treated and if it doesn’t work, oh well, that’s the accepted therapy. There is no dose proportionate healing with these inactive b12s because it all has to go through this keyhole. Some people are totally incapable of converting these to active forms because they lack the enzymes or ATP
2) They take active b12 as an oral tablet reducing absorption to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to binding problems in the person whether genetic or acquired.3. They take a sublingual tablet of active b12 and chew it or slurp it down quickly reducing absorption back to that same 1% and limited to binding capacity. With sublingual tablets absorption is proportionate to time in contact with tissues. I performed a series of absorption tests comparing sublingual absorption to injection via hypersensitive response and urine colorimetry.
3) Of the many brands of sublingual methylb12 only some are very effective. Some are completely ineffective and some have a little effect.
4) For injectable methylb12, if it is exposed to too much light (very little light actually is too much) it breaks down. Broken down methylb12 is hydroxyb12. It doesn’t work at healing brain/cord problems of those who have a presumed low CSF cobalamin level. That requires a flood of unbound methylb12 and adenosylb12 (2 separate deficiencies) that can enter by diffusion. Adenosylb12 from sublinguals can ride along with injected methylb12.
5) They don’t take BOTH active b12s.
6) They don’t take enough active b12s for the purpose.
7) Lack of methylfolate
8) Lack of sufficient Methylfolate, a dose can start more healing than the same dose can complete.
9) Paradoxical Folate Deficiency - Folic acid is taken which can block at least 10 times as much methylfolate from being active inducing folate deficiency even if methylfolate is also taken. These induced deficiency symptoms are often called "detox" symptoms. Folinic acid is taken which can block at least 10-20 times as much methylfolate from being active inducing folate deficiency even if methylfolate is also taken. These induced deficiency symptoms are often called "detox" symptoms.
10) Lack of l-carnitine fumarate (rarely ALCAR), the 4th of the Deadlock Quartet
11) Lack of other critical cofactors.
12) Lack of basic cofactors
13) Glutathione, glutathione direct precursors, NAC and /or whey is taken causing what is often called "detox" while actually being induced folate and b12 deficiencies.
14) Having many additional supplements and herbs of unknown interactions and effects.
15) Too much B1 and/or B2 and/or B3, somewhere between 30-100mg daily (divided 2 doses) of any one or combination.