I'm fairly new here and have not been diagnosed with CFS/ME ( although I suspect I have some form of it.) I do have macrocyctic anemia. I've had only minimal testing done. So my questions are: If your methylation cycle is messed up and you have genetic indicators MTHFR ++,CBS ++ etc., will you need to monitor the B12 and folate (methylation process ) for the rest of your life? Will I need to take b12 and folate forever? Up until now, I've always been fairly able to cope and bounce back from my health challenges. This time around it is pretty humbling experience.