I have read yellow urine may be a sign of viral die-off when on methylation supplements. I take up to 25 mg of methyl B12, P5P, Folate, and a B-50 complex and it works great. However, the dark yellow urine doesn't stop. If I stop the supplements for a day or two, eventually the dark yellow urine will stop, and I will feel feel worse. Happens every time. While I'm producing this yellow urine, my anxiety and chest pain is greatly reduced. More than a pharmaceutical (even the controlled substances) could ever do. My head is perhaps a bit clearer as well, but I wouldn't call it clear. It changes my perception of the surrounding environment significantly and makes it much more pleasant. Now, if it is a virus (I really suspect that may be the case), what virus can cause the symptoms that are greatly reduced by my methylation supplements? Viruses I've been tested for: • Epstein Barr Virus PCR (not detected) • HHV-6, IgG Antibodies, Quant (equivocal for previous exposure) • HIV (negative) • West Nile Virus Antibody, Serum (negative) • Hepatitis C (negative) • Varicella Zoster IgG (2.41 - High) Range: 0.00-0.90 • Hepatitis B Screen (negative) • Hep A Ab, IgM (negative) The only other thing that came back positive was a bacterial infection Lyme (being treated). I also had possible previous exposure to Rocky Mountain Spotted Fever. Any ideas on what other viruses I can be tested for? Is Varicella Zoster too elevated, or is that normal? None of my doctors seemed concerned. Is there a good broad-spectrum antiviral that I could try without positive viral titers? I don't really know anything about anti-virals as I've never been on them before in my life.