I've been on Fredd's P for a few months. Experienced energy (!) at first, now having a real problem with sleep. Wake up feeling good, but crash within a few hours in a way I usually don't. After 4-5 hours of additional sleep, I wake up refreshed. My sleep cycle is tightly controlled with dawn simulation and light boxes. Except for the new naps, it has not changed any. Was reading around last night and found a post about B12+melatonin/serotonin, describing the "heavy headed" fatigue I'm experiencing. It's not brain fog - it's... like a mental thud. This could explain my sleep problem. I've been on SSRIs for seasonal affective and experienced similar sleep comas. I am definitely a low-dopamine/undermethylated type - being chemically "overstimulated" just does not happen. By anything. Ever. My Q: how do I mitigate the sleepiness and proceed with B12? I've worked up to 5mg/day of mb12 and recently added adb12. I take metafolin as directed, but kinda think I might feel better without it. Hard to tell and don't fully understand its role with my mutations. Also taking recommended cofactors (alcar/zinc/sam-e). In the past, alcar has been mildly activating. Just added in carnitine to see if anything magical happens. My serum B12 has always been quite high, without any supplementation & on a vegetarian diet (I now eat meat). MCV also elevated, though no doctor has ever been concerned about that either. 23&me says: VDR taq +/+ COMT v158m +/+ COMT h63h +/+ MTRR a66g +/+ MTHFR a128c +/- BHMT 2 +/+ BHMT 4 +/+ BHMT 8 +/+ CBS c699t +/- I've been trying to understand all this, but my brain just isn't getting it. THANK YOU for any help.