For those that don't know, vitamin B12 and methylation for me is a double edged sword. The vitamins make me feel a thousand times better, but it puts stress on my liver and kidneys. Lately I have needed much less B12 as the cycle seems to be (somewhat) restored again. Well, first it was my liver and dark urine. I retained some fluid throughout the day, but even with the troubles my body seemed to get be able to get most of it off on its own. I had a liver scan that indicated chronic liver disease a while ago. I started on alpha-lipoic acid (with vitamin e, vitamin c, and selenium) and it made a huge difference and helped the fluid retention symptoms (delayed urine emptying?) quite a bit as well. However, large doses of alpha-lipoic acid increased neurological symptoms, but after taking frequent small doses throughout the day (Andy Cutler style sort of), I can tolerate larger doses fine. My liver seems better. It doesn't seem full, and consistently has a nice percussion sound now. Liver enzymes are now perfect. However, my body is now having trouble dumping fluid. I upped the ALA dose to 600 mg last night and this morning, and I lost 7 pounds in 10 hours. Not quite sure what to do. Doctors never seem to know what to do so I am always hesitant to go. I'm wondering if it the antioxidant nature of ALA that helps a lot. I was thinking about adding Acetyl L-Carnitine since it can possibly help kidney stuff, and I read it may help CFS symptoms as well. I know I am just guessing, and may end up with another useless supplement, but despite the collection of useless junk, this has been the way I have figured out what works and what doesn't. Anybody know anything about Acetyl L-Carnitine?