Adding the adB12 & methyl folate back in did definitely seem to help. I slept better and even had some cramping in my calves when I got up the first morning! On the 3rd night I woke up with symptoms, minor but enough to keep me awake. I took some CL mB12 to get back to sleep, but couldn't sleep much past 5am. Hopefully that won't be a regular occurrence. The shots are a hassle so I'd hope they would *replace* the CL and let me sleep through the night without additional sublingual B12. I also stopped taking 5HTP about a month ago, wondering if the B12 alone would be enough to let me sleep well. The 5HTP never addressed my B12 symptoms, but it just made it easier to sleep through the night and go back to sleep if I woke up. Gonna start the 5HTP again tonight. BTW @Freddd, do you take the methyl folate sublingually, or can I just swallow those?