I know that I have posted this before in another thread, and I feel like a broken record since this has been going on for 7-8 months or so I think. Anyway, I am still all alone on this one with no answers, and I am increasingly concerned. My liver enzymes were high. I went on Alpha Lipoic Acid (does most the work) along with some other supplements, and my enzymes came back to normal, but my symptoms didn't stop. So, I made my doctor order a ultrasound, and it came back with "heterogenic echotexture of the liver", "enlarged spleen" (mild), distended gallbladder (but not abnormal?). Overall impression by the radiologist was chronic liver disease. My doctor wasn't worried, but since my symptoms have been so persistent and consistent for so long, I am becoming increasingly worried. When I got sick in 2008, I was on an arsenic contaminated well in Tahoe drinking tap water for a few years. I by no means think this is the cause of everything because all my biomarkers show otherwise and I had chronic lyme disease and my herxes (that word still bugs me) were out of this world. I had/have bartonella as well that is more or less under control now. However, I feel that the infections are just about gone, and I am left with this potent toxin. Why do I think it's a toxin? When I take B12 plus everything else, I can go from feeling absolutely horrible to feeling fine. My urine concentrates to a dark yellow color (I am well aware what colors vitamins turn your pee. That's NOT it), and it becomes foamy. So all of my symptoms are better when My liver/kidney function is impaired and I can't pee! I don't get it. This is the direct result of methylation. However, I can reverse the blockage with Alpha Lipoic Acid, but I will eventually crave more B12 or my nervous system will go nuts. After many months of methylation and intense detox, I had blood levels of arsenic checked and they were 8 g/L. This is well within the LabCorp range, but I believe the range is designed for acute exposure, not chronic. Looking at literature, it's clear that such a value may represent chronic Arsenic poisoning. Freddd commented before and said that arsenic would be rapidly methylated I'm not so sure that that adds up in my case. It is absolutely critical that I take the B12, and I can't go without it for more than a couple days. I had continuous methylation for a few months where I didn't need the supplements, but that stopped. So, a couple things look plausible to me: Porphyrins and Arsenic toxicity. Perhaps it's just something like toxic porphyrins. I have hair and urine testing being ran now for metals to see if I can get a clearer picture. I have jumped states before any methylation, and I currently have no known sources of arsenic exposure besides the trace amounts that's in virtually all water. The amount of arsenic in my drinking water is negligible. I feel left in the dark to figure this out on my own (I ordered my own tests), and I am lost. Sorry for the long-winded post. I attached my info about arsenic below.