New Atmosphere, New Vision: Gibson and Whittemore Kick Off Invest in ME Conference 2016
Mark Berry reports on Dr. Gibson's introduction and Dr. Whittemore's keynote speech, at the 11th Invest in ME International ME Conference in London.
Discuss the article on the Forums.

B vitamins "honeymoon" over...

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by PeterPositive, Jun 4, 2015.

  1. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    Hello,
    the fading effect of B vitamins over time has been reported frequently by people here.
    In my case it's not just about the folate/B12 combo, it is literally all of them.

    Exactly 1 year ago I was slowly upping my dosages and getting significant help in terms of mood, energy, digestion etc... A couple of mgs of methyl-B12 per dosage would reactivate my cognition and provide some stamina, and 1/2 lozenge of sublingual B complex was also very helpful... at times even too much, with a bit of extra anxiety.

    Fast forward to the last 3-4 months and all those effects have slowly faded away, to the point that these days they work more or less like sugar pills.

    These days I can take up to 15mg of methyl-B12 and 5mg of methylfolate and get minor effects, if anything at all.

    B6/P5P and B3/NADH also used to have very good effect and provide good support. Now they are as good as glass of water even at high doses.

    I am really puzzled. Evidently I have replenished all possible deficiencies and there's nothing more to be gained? If that's the case I wonder why I feel worse than 8-10 months ago, where I might have allegedly been deficient.

    I am wondering if folks here have had a similar experience and how they have interpreted the decline.

    thanks
     
    Helen likes this.
  2. Mary

    Mary Senior Member

    Messages:
    2,744
    Likes:
    6,132
    Southern California
    @PeterPositive - I don't know what to tell you. I think I've maintained the gains I got from starting methylfolate (was already on methylcobalamin) some 5 years ago and P-5-P about a year ago. I'm not improving any more, but I'm not backsliding either. Years ago I took NADH (had to take 20 mg. a day to get results) and it was fabulous for about 10 days and then it stopped helping me so I don't take that any more - too pricey with no noticeable results.

    I presume you're on top of your potassium requirements? I have to take about 1200 mg. a day or else I get hit with fatigue from low potassium.
     
    PeterPositive likes this.
  3. dannybex

    dannybex Senior Member

    Messages:
    3,196
    Likes:
    2,172
    Seattle
    Just guessing here Peter, but wondering (as I am in my own case) if in concentrating on b and other vitamins, if we may have depleted minerals or disrupted their ratios, especially trace minerals.

    And with so many taking such high doses of mainly B12 and folate, I do wonder other b vits become depleted, like b2 and b3 (both needed in the krebs cycle), and especially thiamine, a deficiency of which almost mimics the symptoms of ME/CFS:

    http://en.wikipedia.org/wiki/Beriberi
     
    sb4, TheChosenOne, TigerLilea and 7 others like this.
  4. helen1

    helen1 Senior Member

    Messages:
    972
    Likes:
    1,364
    Canada
    @PeterPositive I've been trying to figure out exactly the same thing. I think @dannybex is probably right - we're causing other deficiencies. I haven't yet been able to figure out which ones for myself. I wish freddd were back just to hear his ideas.

    I'm trying extra B1 again next although I did try a week of loading it some months ago and seemed to get a small improvement. I stopped for fear of unbalancing the Bs.
     
    PeterPositive likes this.
  5. drob31

    drob31 Senior Member

    Messages:
    1,244
    Likes:
    725
    What if someone who is running into this issue has a nutraeval test done. That should show if they high levels of B12/folate are causing deficiencies.
     
  6. Tammy

    Tammy Senior Member

    Messages:
    1,070
    Likes:
    1,401
    New Mexico
    I have never felt comfortable taking a supplement every single day for long periods of time because of the possibility of creating deficiencies or imbalances of some sort as mentioned above.....thus I pulse and give myself complete breaks off supplements.
     
    Last edited: Jun 4, 2015
    GoodVibesOnly and Gondwanaland like this.
  7. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    @Mary @dannybex good point about mineral imbalances. I am going to investigate this in the next days. I having them tested in RBCs and serum.

    Honestly I cannot say if I have any symptoms of mineral deficiencies. I take Thorne's Picmins every day for trace minerals but I don't do well on oral potassium or magnesium. In general, due to GI sensitivity, I can't take minerals that are dosed in hundreds of milligrams, if not from the diet.

    @helen1
    About other deficiencies in the B department, I don't know, at least in my case. My B complex daily dose has 25mg of active B1, B2 and 40mg of B3. I have experimented with not taking it vs. taking the regular dose vs. taking a double dose and have noticed very little difference, if any.

    Cheers
     
    Helen and dannybex like this.
  8. Helen

    Helen Senior Member

    Messages:
    2,068
    Likes:
    3,188
    So sorry to hear about your latest experiences. May I ask where you will get tested, in Italy or abroad at an lab available at the Internet? I am considering getting tested too, but as you say it should also be analyzis of the RBC´s.
     
  9. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    I am testing with the European Lab of Nutrients in the Netherlands.
    They offer several mineral panels that include levels in RBC.

    You can check the panels and price list in the left hand corner of their home page.
    http://www.europeanlaboratory.com/

    cheers
     
    helen1, dannybex and Helen like this.
  10. Helen

    Helen Senior Member

    Messages:
    2,068
    Likes:
    3,188
    Thank you, I guess you get the tests requested by a doctor, or is there a way to order them by oneself? They don´t mention this as an option.
     
  11. brenda

    brenda Senior Member

    Messages:
    1,938
    Likes:
    1,467
    UK
    Yes I would say definitely from my own experience that assimilation of b vitamins particularly b12 depends on other nutrients and probably some we don't know about yet. I was unable to take any b12 at all even in beef without having severe mood swings, insomnia and IC flare.

    Since I have been using a treatment (which is probably too far out for most of you :) ) which apparently delivers various vitamins and minerals direct to the cells in the form of frequencies, I can now take liver, beef and yeast flakes with no trouble at all. As I have been using a program that does not specify the vitamins I cannot say but for minerals I am using various ones.
     
    sb4 and Gondwanaland like this.
  12. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    You can order with or without a doctor request.
    Cheers
     
    Helen likes this.
  13. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    Not to worry, nothing is too far out for me :)
    I've explored all avenues, esoteric ones included. Can you tell me more about it?
     
  14. brenda

    brenda Senior Member

    Messages:
    1,938
    Likes:
    1,467
    UK
    It's known as Rife therapy with an electric device.
     
    sb4 likes this.
  15. minkeygirl

    minkeygirl But I Look So Good.

    Messages:
    4,678
    Likes:
    4,647
    Left Coast
    PeterPositive likes this.
  16. PeterPositive

    PeterPositive Senior Member

    Messages:
    1,426
    Likes:
    1,033
    Thanks. Good product, with a bit of copper to balance the zinc. At the moment I am taking copper separately as last time I checked I was low on it. This one might replace the PicMins but it lacks the Selenium.
     
  17. girlfromeurope

    girlfromeurope Senior Member

    Messages:
    129
    Likes:
    36
    Belgium
    b vitamins work with magnesium and zinc.
    If you don't do well on oral magnesium you can try transdermal magnesium.
    And make sure you also take some b6 in active form because it helps with absorption of magnesium and zinc.
     
    Last edited: Jun 11, 2015
  18. Ninan

    Ninan Senior Member

    Messages:
    511
    Likes:
    313
    Haven't read the whole thread but I experienced a loss of effect for years. In the beginning I didn't need any other vitamins but I had to raise my B12 dose regularly to keep it working. Until one day it didn't work anymore. The key for me was getting the co-factors right, I must have run out of them. Now I have great effect again.
     
    GoodVibesOnly, Gondwanaland and JCamp like this.
  19. GoodVibesOnly

    GoodVibesOnly

    Messages:
    46
    Likes:
    39
    @Ninan can you please explain what you mean by 'getting the co-factors right'?
     
  20. kel88

    kel88 Senior Member

    Messages:
    117
    Likes:
    12
    Yes the same here...
    I have to take more and more to feel something!
    Its i guess because low stomach acid!
    I dont absorp anything anymore! Everytime i have to increase the dose to find a couple of weeks relieve but at this point my stomach is just as acid as water i guess and dont absorp thing anymore! Im also lost...
     

See more popular forum discussions.

Share This Page