There is tons of good information on this forum and it gives me some hope on getting my wife's CFS symptoms improved. It seems we have reached the limits of what the doctors can do. I Need a little help with the B12 protocol. I am going to try and be concise and give as much background as I can. My wife has been on Prozac or other antidepressants since she was a teenager. She has OCD and anxiety issues. She has always napped excessively and skipped a lot of school to go home and nap in high school. It was never a fatigue issue. She played volleyball in high school and ran 5k's in college. Two years ago (shes 25) she started having serious digestion problems. Had a colonoscopy/endoscopy and was diagnosed (if thats what you want to call it) with IBS. Soon after CFS/FM symptoms set in. She went to Dr. Patricia Salvado in Houston and was given glutathion injections (her ATP was low) based on Richard A. Van Konynenburg theory. This had no effect and her other doctors advised her to stop seeing her. Since, she has seen 2 internists, an endocrinologist, another GI doctor, had a sleep study, and I can't recall what else. None of the docs found anything except the GI tested for Celiac and ran a b12. April 2010: Her B12 was 280 and vit D was at 36. GI put her on oral b12 (had spasms when falling asleep). May 2010: Her b12 was @ ~300. The GI recommended injections. 6 shots in the first two weeks, then 2/month. Her symptoms seemed to subside some except still extremely tired and would sleep 12 hours/day. August 2010: Saw sleep doctor, had sleep study, no major abnormalities. Fatigue seemed to return. Sept 2010: Tested b12 again and it was at 280 (it went down). She has tingly hands some nights. Major digestion problems. Noisy stomach. Extreme fatigue. Sleeps excessively. Muscle pain/FM. Soar to the touch, sensitive skin (she turns red when drinking or stressed) Every other month has a soar throat/pneumonia/bronchitis. If we both catch the stomach flu, she will have it two weeks and I will get over it in 24 hours. She gets antibiotics 8-10x a year. Sept 15 2010: Began B12 protocol from WD via Freddd. Started the ramp up: "To minimize startup effects, start with adnosylb12. This turns on the mitochondria before the nervous system. There is some nervous system startup due to limited mb12 conversion and due to neuronal mitochondria startup, but only a fraction of what occurs with methylb12. There is no large amount of unbound mb12 which produces large rapid changes. Then add TMG, the gentlest of the methylators. Then add SAM-e, then methylfolate and finally methylb12. By the time the mb12 is added, only those effects due purely to the mb12 itself will occur without the mitochondrial startup and the methylation reaction. After that add the l-carntine to finish the mitochondrial startup.with adb12" She never had any reaction to anything except once. She took a one-a-day multi-vitamin and felt like she was itching all over when going to sleep. Tried the one-a-day the next day, no reaction. Sept 30: Decided to start over and began just taking one of everything, looking for any kind of reaction. She has been taking all the supplements and co-factors and has seen no improvement or really any reaction at all. Currently 1 of everything: Calcium, Magnesium, A, D,E,C. Potassium, TMG, SAMe, Jarrow Formulas 5mg Methyl B12,Country Life Dibencozide, Solgar Metafolin 800mcg, Jarrow B-Right b-complex, Omega 3 fishoil, Zinc, and L-carnitine fumarate. Does anyone have any suggestions on how to move forward? Stick with it? Add more of one supplement? Take some away? Start something completely different? Shes has had a lot of blood work done and I am in the process of getting in a spreadsheet. Let me know if you need more info. Thanks for your help.