Hi, I'm back from the unconnected while out in the woods. I had an old computer for writing but no wireless as my current portable became infected a week before I left and I didn't have time to deal with it. In the last 8 weeks the skin all around my nails and on fingers and toes stopped peeling off and being rough and never healing. This happened also after starting Metafolin the first time but went away with the glutathione precursors and the rough peeling resumed. I also put on 35 pounds in the next 18 months after glutathione (precursors) no matter what I did. Now with the skin once again heeling I have lost 20 pounds eating and exercising after putting on the weight no matter what I did. The only change was the glutathione precursors. At the same time I had the worst seasonal allergies I have had in 7 years and some resumption of chemical sensitivity. Finally my need for folate has come down. While I added folinic acid in this period it was after the correction was already occurring and it is not possible to say if it has had any effect. I am down to under 2400 mcg of Metafolin and folinic acid per day and slowly decreasing from 4800mcg or more required to prevent outright folate deficiency during the past 18 months. Despite that my mcv increased from 96 to almost 102 in the 16 months following the glutathione precursors. I will be curious to see if it goes back down now that everything else is correcting. I also had a bout of hypokalemia after 10 days at 7200 feet, perhaps caused by kicking out more red cells to accomodate to altitude or possibly red cells being matured at a smaller size after finally getting rid of lingering results of glutathione precursors. We shall see again at my next appointment. I am feeling better again. However, running around in the sun for a few weeks always does that. Also, I have decreased my prescribed diuretic to 25% of the former dose. Whether my kidney's are working better or maybe my endothelium has stopped leaking so much water out into other tissues I can't tell. This can happen because of side effects of drugs as well as endothelial failure caused by cellular reproduction failure from mb12/methylfolate deficiency. Starting a few several weeks before my departure and continuing on my vacation the last few weeks my body has been returning to the pre-glutathione trial condition. On the whole that trial was a disaster lasting 17 months past the end of the trial. My neurology has been improving again lately. I can't explain the mechanism that allows glutathione to disable methylfolate for 16 months following discontinuance but it is there. It also disables mb12 and adb12 to some degree. It's interesting the rapidity with which the skin on my hands and feet healed recently. It is good to be actively healing again after 18 months.