Thanks, Freddd. I crashed yesterday. Was able to have a wonderful day from 9-4 running errands and shopping.. felt somewhat near normal. Got home and knew I was toast. I didnt know adenyl is not used up.. was thinking maybe I need more and maybe I do for reserves.. ?? Took 4 1 mg jarrow M12s today and will take one more at least. I was taking 4 mg total per day. Also took half a AB12 (4.3 mg) and more methionine, which has helped me in the past. Wondering now if daily activity, pushing the muscles.. which i did... I could feel them working and flexing like when i used to work out and took such things forgranted.. what a great feeling. At the same time, I could tell they were not recovering well. I've been looking int o my genetics. I am MTR++ which means both genes in the pair are defective. This gene is supposedly responsible for "using" MB12 specifically. ++ indicates I am a MB12 guzzler and use too inefficiently, too fast. One MTRR gene is hetero +-. This one is involved in recycling B12.. so this can be slowed down due to this gene. So despite my COMT++, ++ status which honestly I am abit confused about though am warned not to take too many methyl groups because of, I may very well need a continual supply of MB12. I dont understand how small amounts of MB12 can make up a deficiency or what exactly defines that. It seems to me if one is always needing to "reload" then one is at least dependent. If the body needs to function and one constantly needs to reload to do that, then are we talking repair stage or to function stage? If you stopped MB12 would you go downhill or stop progressing? Regarding your RBCs.. are you sure your methylation cycle is balanced? Thank you Lena and Sunday for your updates. It helps to hear.