No, not that I'm aware of. But I had some urinary symptoms a couple of months back that started after 3 consecutive weeks of glutathione shots. I had a shot last Tuesday, don't plan on having any more at this time. Had a little setback. Even though the second 1/4 mb12 tablet was at 5:30pm I couldn't get to sleep until around 4am. Even with extra klonopin and some benadryl. My heart rate was staying about about 15 to 20 beats higher than it would normally. I have an easily activated nervous system, for example I can't tolerate much caffeine at all. I'm going to step back and start the mb12 at a much lower dose and climb slower. Going to stay with 1 B-Right a day for a few days also.