Hi Cristina, A balance is needed. Also a large enogh dose is needed that eventiully the bodies need is fully met and an equilibrium is reached. It appears possible to take so small a dose that equilibrium is never reached, at least not in a reasonable amount of time, and startup responses continue unabated indefinitely. Good luck. Some people have reported taking 25,000 mcg for a couple of days 5000 at a time and then being able to drop back to 1000mcg and have no startup response from that.