It's been said on this forum before, but high serum B12 levels may actually indicate a B12 deficiency; it's the cerebrospinal fluid that needs to be tested for the true story. Practical demonstration of my B12 deficiency is enough for me, I have no desire to have my spine tapped and also very little cash to spend on healing; I can think of a number of much more effective ways to spend money on healing than that. On the other hand, it's good some people are being tested so the medical community might have some of the kind of data it's used to. I think you kind of develop techniques for holding the lozenges in the mouth longer. I put them by my bed and slip them under my tongue when I first wake; I've never waked easily and CFS has made it even more difficult, so I doze off with them under my tongue and when I wake an hour or more later they are still there. I think getting them far enough under the tongue kind of puts them in a pocket where they are protected from excessive saliva and so forth. David, thanks for the upper lip tip, I'll try that; your upping-the-methylfolate tip was excellent so I regard you as a person whose advice should be considered! Maybe I have a dry mouth or something but under my tongue is mostly where my lozenges get parked, I move them around only if I get that weird sore-spot thing they sometimes cause. I've also been experimenting with taking the b12s in sequence, instead of all at once.