I have an update on my post glutathione precursor experience. I am now about 1 year post glut trial. I tried to reduce to 3200mcg of methylfolate as 800mcg had previously been effective. I moved that back up to 4000mcg but not enough in time to stop the development of angular chelitis which is my hallmark folate deficiency symptom that is always on the pivot point. I have gone back to 4800mcg daily but in a slightly different configuation. I am now taking 800mcg with my morning premeal items such as SAM-e and l-carnitine fumarate. I'm also taking 800mcg at bedtime with my bedtime injection. The rest I am still taking in 2 batches with mealtime vitamins. I have found another apparant frequency or halflife effect. The angular chelitis is again in full retreat and suddenly my feet are regaining feeling by leaps and bounds. They are now, a full year downstream from the glut trial, back to where they were before the trial with the numbness retreating rapidly. Taking the two additional doses daily but to the same total appears much more effective and appears to make the mb12 more effective. The serum half life of Metafolin is about 3 hours. So even 6 hour intervals allows 2 half life periods between doses. So maybe this is the next step I've been looking for, to notch the healing up another step. If anybody else tries this I would really like to hear about it.