Thanks velha508 and Sunday I have acutally been working on my gut issues for 6 months now, and have seen a significant improvement. This has been down to excluding wheat then gluten, cows milk products then all dairy products, coffee alcohol and sugar. The lastest is lectins. I also take digestive enzymes, juice green vegetables and eat a lot of vegetables testing everything with self kinesiology. I tend to agree with Hyppocratise who said that all disease starts in the gut. The only problem I have had was when I tried Fredd's protocol and had an extreme reaction, and even felt suicidal. I agree with dreambirdie that what happened was due to mercury being mobilised, and she proved it for herself by having a test done. I rememeber Andy Cutler's site where people are chelating mercury and reading of others who got suicidal at times so I am not an unusual case at all, I just should not have taken methyl b12 in such a high dose. The improvement has been general, and also I have some days when my clarity of thought is better than has been for a long time. It has been a very bumpy ride psychologically though and I have had mood swings and bad days but then I feel better than ever for a day. My bowel function is much better, my skin is better and my joints have less pain. I am having a DSA done to fine tune things and think that I can probably start on the simplified protocol soon once I have a methylation test done.