Hi Klutzo, My cholesterol is one of the things that I have tested annually. It has fallen slightly since starting all these things and the HDL:LDL has remained basically unchanged. I can see no effects at all really as the slight fall was only 5 points and that is well within normal annual variation. My approach as been to stop and start things several times to find what is repeatable. After adding something I often retry things that didn't make a difference before. There are some things nobody is going to feel so it is difficult to advise on that. And sometimes the effect is quite indirect, ie finding that chondroitin/glucosimine/msm makes a difference but only when you have TMG on board. Combinations can be everything in this.