Hi Lena, I was reminded of a rare effect with Omega3 oils on another forum, anxiety. Finds a balance of adb12 that is comfy for you. Once it parks in the mitochiondria it doesn't leave very quickly. I take 15-18mg once a week as a single dose timed with my injection to penetrate the CNS/CSF most effciently and more often or more does nothing. On the other hand the mb12 leaves so quickly I can tell the difference between 1 10mg injection per day and 2 or 3 such injections per day. Good luck.