Hi Lynn, Folate insufficiency increases inflammation. It is spoken of in research that the body uses it's own "triage" system for allocating folate. When healing starts on one layer it appears that all the folate needed for that level is allocated to it and reduces folate at other levels which increases the inflammation in those other layers. At least that is the way I would describe it based on my own experience of periodic folate insufficiency hundreds of times. Chewing a b12 tablet and swallowing reduces the amount of b12 to about 1% from an achievable (with Enzymatic Therapy) of 25-33% (max range). The theory that HyCbl should work better for some genetics may come from massively reduced effectivness. It doesn't cause all those nasty side effects of healing like low potassium symptoms, low folate symptoms and in reference to nerves, the increased feeling of pains that freshly stimulated nerves that hadn't been working have. When an area comes back from not feeling, what is felt is the damage; with shooting pains, intense steady pain, painful tingling, more awareness of the shrinkage and therefore tightness of the muscles and all that. Again, I can only speak from repeated experience. Active healing can be painful. Shutting down the damaged nerves reduces the pain. What I said to myself 11 years ago is that the whole thing is counter intuitive. Many people say "what awful side effects" from the increased pains, the misery of low potassium and increased inflammation and pain from donut hole paradoxical folate deficiency/insufficiency and make sure that they never again do what could heal them over a period of time. I don't know of anybody who has healed from FMS/CFS/ME doing it with HyCbl. Many have some improvements and other things get worse. In every study done on HyCbl (and they are not designed to actually produce healing) there is about a 2/3 chance that a subject could have some improvement and 1/3 have no improvement at all for the studied symptoms. I have been offering information here and debugging my hypothesis and protocol for 5 or 6 years now. In all that time I have not seen anybody at all announce that they have corrected their problems to the point of returning to work, walking 5 miles daily, climbing a 2000 foot vertical hill, get back into decent aerobic condition and get their muscles restored. So whatever people interpreting the tests to mean advise on HyCbl doesn't appear to work.. I can only chalk up all your apparent contradictions to various ways things work partially or not at all. The whole thing is complicated. Where the people are having results the conversation changes all the time as they no longer have a problem with one symptoms set and turn their attention to others. That is why the active b12s and folate lead to need for more folate, need for potassium, need for a dozen other things, until it gets down to making adjustments in b1, b2 and b3 because those are what lead to specific predictable results. HyCbl rarely leads to solving a succession of half a dozen things or more. So far nobody can describe a healing path that starts with HyCbl through the flags of healing being turned on to secondary and tertiary insufficiency or over sufficiency symptoms. There are no predictions that can be made ( nervous system turning on, low potassium and folate shortly after starting) and predictions of what works for that after the initial things are cleared. And of course these are multi substance problems. In my opinion it works out better if one thinks in terms of partial methylation block, methyltrap and partial ATP block. HyCbl doesn't generally correct these and can even cause them over time. MeCbl and cofactors can often correct these if given a chance. Damage can take years to heal if at all for some damages. I was unable to rate the CL. It seems pretty good, for the body anyway. It dissolves so fast I was not able to absorb enough for it to penetrate my CNS sufficiently to give a rating as those are my active symptoms. Good luck. Try 10 or 20 different brands and look for the brand(s) that blows your socks off most, that stirs up your symptoms most. My strategy was to look for those things that stirred up the symptoms most. Those that were stirred up the most tended to be the first to improve. In 3 weeks when I went back to my new doc after the first visit after which I started the MeCbl, everybody in the office could literally see the difference. I felt so much better, had some energy, my whole body language was different and I no longer looked like I was at the edge of death. It was tumultuous and painful but a lot better in a month of aiming towards maximum. Each time things backed away from that maximum I tried to find what would restore that, at first an increase in MeCbl, then adding AdoCbl, then L-methylfolate and other things and finally LCF. It was so easy in those days with so many active symptoms that I could watch change. Now it is down to a hard core of 10 symptoms or so from 200 I started with.