[/quote] Hi Pam, MeCbl is considered by researchers to have neurological properties totally unmatched by any other kind of cobalamin. Also, Methylfolate is the form that penetrates the brain. I would take the irritations as evidence that they are making it into your brain and being effective in the damaged already brain. The moods appear to be the limbic system which repeatedly causes the symptoms mentioned. Activation of damaged nerves is PAINFUL, and how that gets expressed depends on which nerves it is. The severe headaches, which I used to have, appear to be usually severe pain in the muscles or inflamed veins on the head/neck or nerve pain in the nerves of the scalp etc and they stereo-locate into the head. To get your Krebs cycle going take AdoCbl and LCF as well as methylfolate and MeCbl. It is a 4 way deadlock.. I've been through it and healed. The theories you choose to use determine if you can heal. Most of the theories won't result in healing. There are dangerous side effects like some of the induced deficiencies or high BP from CoQ10 (causes headaches too) and quite a few unpleasant side effects that are flags of healing.