Really?! O dear. And you too have the C677T mutation, right? Do/did you have a B12 deficiency as well? (Mine was 119) Well, high time to reconsider my daily dose I think. I've decided to cut the Metafolin dose in half, because mayby one could define this strange pressure around my face as headache? Headaches are a side effect with methylfolate, at least that's what I have read. I have also taken vitamin B6, niacin and one capsule of Bio-curcumin phytosome (Now Foods). Hopefully my head pressure will go away, then I'll know for sure it was because of the methylfolate. When I think of it, when I started with methylfolate, 200 mcg/day, I did not have it. But that 200 mcg sure had effect: my mood improved and the fog was lifted. I'll stick to my mB12 dose for now, I have no longer tingling sensations or electric shocks, last week I had, and my speech (using the wrong words without knowing) seems to have improved a bit. I'll continue the aB12, I am still unable to go up 1 staircase without getting short of breath, same for taking a shower or getting (un)dressed. I definitely want to improve my physical strength. Thanks for mentioning my dose may be too high, Adreno.