Thanks Rich, I edited my post above slightly to make it a bit clearer for anyone reading. Thanks for perservering to read and help. I was reading that B12 and folate both RAISE histamine, so wondered if I had a histamine reaction , and, if so , is that why I have had problems taking B12 and folate supps. The headache only came on after taking the 100mcg Solgar Metafolin so I know it caused it, but I'm assuming the levels of histamine were already primed highish from the meal, allowing a small dose of folate to push over the threshold.(although its a blurred threshold with a gradual comeon which could be interpretd as a chronic fatigue style tiredness and head not quite right especially around eyes?) I was trying to suggest that maybe IF the Metafolin caused the headache by raising histamine levels over a threshold, then maybe for me and maybe for others who are not able to tolerate B12 or folate, maybe we should be looking at taking something to reduce histamine first. Maybe this is why some of us are having negative reactions to B12, and if so, would taking Daomin or similar beforehand allow us to take B12 without the negative reaction? I believe I need the B12 in the long run, I have ben trying to take it since 2002, and I dont really buy into the detox line, thinking its more causing shortages or taking over thresholds(ok mercury and some other toxins moving sounds valid) Does anyone know if a histamine style reaction also cause the increase tingling and reddish/puplish palms of hands and soles of feet? (I didn't get that this time(I dont get this reactio from folate), but have previously when taking B12 as well as wiped and headachy). This is my typical B12 reaction.(less from a methylcobalmin sublingual, more from a hydroxocobalamin injection which I believe delivers more B12 to me) Just wondering if if ordering that histamine lowering product from iherb or Daomin or the other product in London and taking before the B12 would help? and if it would help others who are having problems taking B12 as well? Anyone else think this may be why they don't tolerate B12 too also if I need to learn about histamine, which I find very confusing, where is a good place? like does high histamine cause these bloodshot eyes I've been getting sometimes..can't figure ourt why I get those..