liquidsky: yes, several of us who started rich's simplified protocol back before PR and before Fredd began posting here.. ran into problems with methylation support causing intensification of inflammation. Most of those people have quit the protocol, or suspended it while they attack pathogens, or are trying other things to combat inflammation. Prof Richard Deth was just lecturing today at Autism ONe about the damaging effects of chronic oxidative stress on the brain. it's no trivial thing. Thing is I don't know if the intensificiation of inflammation we are experiencing affects the brain as well as the body. Personally, I decided it wasn't smart to tough it out.. but it's a trade off.. my brain doesn't really function w/out b12 and folate.. ..so I actually took low doses of both today. (think i just contradicted myself there..,so clarification.. I tried to quit..but occasionally i take low dose b12 and folate occasionally because I find it hard to function without it.) Sorry. Clear as mud, right? Plus, and it would be great if Rich could comment on this, I assume that if we have partial methylation blocks, we are accumulating DNA damage the whole time we are not treating it. Everything is a trade off.