Hi Lena, With all the flap going on I appreciate your support in this. Personally I couldn't wait for another 100 years of the usual pace of this kind research to prove anything. The drug companies research is all towards finding the nex multibillion dollar hit drug, not understanding the basics of a vitamin. When it comes down to it I'm a software developer and consultant who sells to companies. I've made my living solving their problems. This time I solved my problem and that of some others. In doing so I lost faith in the research establishment and their methodologies. I also saw that everybody along the way was comfortable with having my life flushed away as long as they followed accepted protocol so that they were not vulnerable legally speaking. I was rapidly headed towards a wheelchair and nobody had a possible solution except the leading edge of Japanese research. This morning I have the mb12 under my upper lip. Is it as effective under the tongue? It appears to work at least as well. I find it is good to move the exact locations around so as not to develop irritations. I have noticed since being on 1 mb12 that my sleep problems are worse, I require more xanax to get some sleep. This is pretty normal as the metabolism and neurology is shifting. It takes a little while for one's system to adjust. When it does sleep usually normalizes. One of the side effects warned about for methylfolate is that it can produce drowsiness at first. Sounds useful here. It restored my sleep to normal dreaming. I used to sleep less than 5 hours of poor sleep. Now I sleep 8 hours of good sleep. Any time you are comfortable with starting it is good. Methylfolate will modify the experience and let your body get to work adjusting. It is often a significant missing factor. I find it sad that the tests are pretty useless in predicting who will respond. They can find somebody seriously low but not predict who will benefit, who has sufficiency. Optimums are different than minimums. This morning woke up with some anxiety, not bad but its here (especially after reading some of the other posts, I try to only concentrate on your posts). I do understand. Last night I started remembering back to 6 years and before to how fearful I was then. Anxiety is a b12 deficiency symptom. I also think that being repeatedly mistreated by the doctors produces a great deal of fear. It sure did for me. I think that being suspicious of all the treatments of the week is a normal outcome of our for profit system. As the Mothers of Invention album name put it in making fun of some other bands "We Are Only In It for the Money". It is hard to measure improvements but looking back to a month ago today I am much improved It is hard to see the differences except over time. 1% a day is not noticable as it happens but over a month it sure is. With all the treatments I tried in the last 8 years not one doctor, alternative, holistic or practitioner of some kind was totally honest with me, they promoted their treatment or supplements for large sums of money without any proof of anyone ever recovering. I went through that too. I disliked it enough that I would never intentionally place anybody in that position. I started keeping track very carefully charting all meds used every day and how I felt. Therte was of course day to day variations. The many practitioners all wanted to claim each tick of improvment but disclaim each downtick. At the end of the month most had made no difference. During those worst years only my chiropractor really made a difference, and then only for certain things with my damaged back and neck. In 3 years he reduced the pain associated with a very out of shape part of my back and certain headaches. I actually gained an inch in height with my back put back into place. All I can offer is that I have tread that path of recovery and understand how and why I recovered. I found the flaws in certain research and it's misunderstanding. It has worked for some hundreds others too. Some are well and some uncovered various other problems. On the wrongdiagnosis site it interesting that almost nobody is talking abbout the b12 protocol, they are applying it. All the talk is about the uncovered comorbidities, brainfog that doesn't clear up right away and carbohydrates in diet and other such "side issues". Good luck and good health.