I have posted before how valtrex and famvir have made a big difference to me. Every few months i take a break, probably to reassure myself its helping and also just to see if i can function without them. Anyway just as in past experiences, within a week i started to feel like crap with return of cfs symptoms. It reminds me just how sick i was. So at the end of the week im back on valtrex, usually with a bit of a loading dose which is 1000mg twice a day for first day then 500mg twice a day, within 3-4 days Im feeling good, actually much better then before my break. This seems to happen in the past as well. I think there is something to having a break, maybe letting these little buggers reactivate again and letting the av's get a better hold of them. I know there was someone on the prohealth board who use to use av's intermittently with good success, Im just not too sure about doing it to regularly in case of becoming resistant to valtrex. I think i will just take breaks when im feeling abit below par after being 'on' for a few months as i think the short break helps the av's work better. Hope this is of interest to someone, like to hear from others who have noticed something similar, or can explain this occurrence.