Autonomic symptoms at baseline and following infectious mono in a prospective cohort of adolescents

[Dolphin]

Autonomic symptoms at baseline and following infectious mononucleosis in a prospective cohort of adolescents.

Katz BZ, Stewart JM, Shiraishi Y, Mears CJ, Taylor R.

Arch Pediatr Adolesc Med. 2011 Aug;165(8):765-6. doi: 10.1001/archpediatrics.2011.124.


PMID: 21810640 [PubMed - indexed for MEDLINE]

now free at:
http://archpedi.jamanetwork.com/article.aspx?articleid=1107566

 

[Dolphin]

Quotable quote perhaps:

The strength of our study is that a difference in reported autonomic symptoms was seen as early as a median of 2 months following the diagnosis of IM, making it unlikely that prolonged inactivity is the explanation.

 

[Dolphin]

Our data are consistent with those seen in adults4 and can be explained in at least 2 ways: (1) Adolescents destined to develop CFS following IM have a preillness disposition to autonomic dysfunction. (2) Adolescents who developed CFS had worse IM (as is true for adults6), as evidenced by worse autonomic symptoms. The data we collected as part of this study do not allow us to differentiate between these 2 possibilities.

 

[Erik Johnson]

"Further studies are needed"

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A Cluster of Patients With a Chronic Mononucleosis-like Syndrome
Authors
Holmes GP, Kaplan JE, Stewart JA, Hunt B, Pinsky PF, Schonberger LB.
Journal Information
JAMA 1987;257:2297-2302
Summary
This is the first published article of the CDC CFS Research Program and reports the findings of our investigation of fatiguing illness in Incline Village, NV.
Abstract
A cluster of 134 patients who had undergone Epstein-Barr virus (EBV) serological testing because of suspected chronic EBV syndrome was investigated in Nevada. Fifteen case-patients were identified who had severe, persistent fatigue of undedetermined etiology for more than two months. When compared with the remaining 119 patients who had less severe illnesses and with 30 age-sex-, and race-matched control-persons, these 15 patients had significantly higher antibody titers against various components of EBV and against cytomegalovirus and herpes simplex and measles viruses. EBV serology could not reliably differentiate individual case-patients from the others, and the reproducibility of the tests within and among laboratories was poor. As a group, the case-patients appear to have had a syndrome that is characterized by chronic fatigue, fever, sore throat, and lymphadenopathy. The relationship of this fatigue syndrome to EBV is unclear; further studies are needed to determine its etiology.

 

[Esther12]

Thanks.

The strength of our study is that a difference in reported autonomic symptoms was seen as early as a median of 2 months following the diagnosis of IM, making it unlikely that prolonged inactivity is the explanation.

I wonder how solid this claim is.