Sorry if this kind of thread has been started elsewhere - the Mods can merge/delete as appropriate. The immune system : I don't find this an easy area to get into at all. I'm assuming there are others out there in a similar predicament. If that's the case, then I draw your attention to this review on Autoimmunity mechanisms :http://www.cell.com/retrieve/pii/S0092867407008380 Just click on "PDF". For some reason this author has written the paper in a way which has made this the most readable paper I've yet read with respect to Autoimmunity. Just a word of caution - it's from 2007, and four years seems to be a long time in Immunology. I think it's an excellent start though. If people find this helpful I could occasionally flag up other particularly accessible papers, and I'd appreciate it if others would do this too. Assuming this does not cause any particular Forum issues of course. Autoimmunity does seems a particularly hot topic at the moment.