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Autoimmunity may play a role in the pathogenesis of POTS

N

natasa778

Senior Member
Messages
1,774
not sure if this has been posted, apologies if a duplicate ..

Transl Res. 2013 Apr 2. pii: S1931-5244(13)00075-3. doi: Autoimmunoreactive IgGs against cardiac lipid raft-associated proteins in patients with postural orthostatic tachycardia syndrome.

http://www.ncbi.nlm.nih.gov/pubmed/23562385

Abstract

Lipid rafts are specialized plasma membrane microdomains that serve as platforms for integrating cellular signal transductions. We have recently reported that autoantibodies against cardiac membrane proteins are present in patients with postural orthostatic tachycardia syndrome (POTS). In this study, we examined the presence of autoimmunoreactive IgGs against lipid raft proteins in these patients. IgGs were purified from the sera of 10 patients and 7 normal controls. Cardiac lipid raft preparations were isolated from normal human heart tissue. The lipid raft-associated proteins were resolved by 2-dimensional gel electrophoresis and immunoblotted against IgGs from each subject. Protein spots that reacted specifically with patient IgGs were identified by nanoLC-MS/MS. Thirty-four such protein spots, and 72 unique proteins were identified. The targets of autoimmunoreactive IgGs include proteins associated with caveolae structure, adrenergic signaling, calcium signaling, cytostructures, chaperone and energy metabolism. Multiple pathways were involved including those that regulate caveolae-mediated signaling, oxidative phosphorylation, fatty acid metabolism, protein ubiquitination, and cardiac â-adrenergic signaling. Our results suggest that cardiac lipid raft-associated proteins are targets of autoimmunoreactive IgGs from patients with POTS. Autoimmunity may play a role in the pathogenesis of POTS.
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M

mari

Messages
8
thanks so much.
2 days now with headache when standing up and just 3 days on methyl b12, folate and adenosylb12 +k gluconate and no sure if the hypotension is side effect of supp or detox and now seen your post i realized that i still have leaky gut and still systemic candida. so no sure how to relieve and prevent symptoms quickly and go on with house chores.
any ideas?
thanks
 
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