There seem to be theories of ME being a viral infection hence treatment with anti virals along with theories that it is an auto immune disease leading to treatment with rituximab. I was wondering if there was some relationship between autoimmunity and viral action and hence antivirals. I found this paper that seems to relate these concepts - hence I thought it might be of interest. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065340/ Not comming from a biological background I'm not convinced I understand the paper but as I see it what they are saying is that were someone has an auto immune disease this will attract B/T cells to the site being attacked. Some of these may contain a herpes type virus, this could lead to the virus becomming active at that site hence causing a relapse. Therefore they suggest the use of anti-virals (partiularly where patients are on immune suppressants). There seem to have been a number of interesting mouse experiments refered to in the paper.