1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Join the National PR Campaign for ME: Power to the Patient (P2tP)
Have you had enough of all the neglect and abuse of ME/CFS patients? Gabby Klein says now is the time for a National PR Campaign for ME/CFS to impress a change. Join the Patient Revolution to restore power to ME patients ...
Discuss the article on the Forums.

Autoimmune pathology in retroviral infection

Discussion in 'XMRV Research and Replication Studies' started by natasa778, Mar 9, 2010.

  1. natasa778

    natasa778 Senior Member

    Messages:
    1,497
    Likes:
    1,369
    London UK
    Autoantibodies in Hiv-Infected Patients That Modulate the Cholinergic Activity of Heart and Gut Tissue

    In human immune deficiency virus (HIV) disease, direct infection of heart tissue with HIV and repeated intestinal infections with opportunistic pathogens are thought to be the main cause of cardiac disease and diarrhoea respectively. A role for autoimmune phenomena may also be involved in the pathogeny of HIV disease. In this study, we demonstrate that immunoglobulins from the A and G classes from HIV positive patients are able to interfere with the function of the muscarinic cholinergic receptors from heart and gut. Both IgA and IgG HIV+ preparations decreased the tension of isolated atria and increased the tension of isolated ileum. The mechanical effect of carbachol was inhibited in both atria and ileum preparations. when they were preincubated with either IgA or IgG HIV+ fractions.

    An inhibitor of muscarinic cholinergic receptors (atropine) impaired the negative inotropic action of HIV+ immunoglobulins (Ig) on the heart and prevented the positive inotropic effect of HIV+ Igs on ileum.

    HIV+ IgA fraction was approximately ten fold more potent to interfere with the cholinergic function as compared to the IgG fraction.

    These results suggest that antibodies present in HIV+ serum may also modulate muscle's cholinergic activity in the heart and ileum from HIV+ patients.

    http://informahealthcare.com/doi/abs/10.3109/08916939309079233?cookieSet=1&journalCode=aut

    http://tinyurl.com/yky8ch8
     

See more popular forum discussions.

Share This Page