Discussion in 'Other Health News and Research' started by Firestormm, Mar 2, 2014.
Via Tate Mitchel and Co-cure
@Legendrew thought you might be interested as well as others.
What did Alan and Kathleen Light find about adrenergic receptors, is it similar to this, or something different?
I can't remember. The above is a small study but hopefully they will repeat it with more patients (and controls) if they can secure funding. Personally I don't tend to follow research in this area very closely but thought it might be of interest to those affected by POTS. I couldn't understand the paper but thought the blog was easier to follow.
Interesting stuff, the sudden onset triggered by infections and female predominance has always suggested such, and now we have a glimpse as to what exactly is 'going on' in POTS. I look forward to a larger study which it sounds they are already planning.
I was reading about some "new" autoimmune antibodies that Vandy researchers were looking for just a few weeks ago. I looked for the "further research" they alluded to, but couldn't find anything.
Must have been just *this* much too early. LOL.
Thanks for posting!
That was adrenergic alpha-2A, so a bit different from receptors for adrenergic alpha-1A or adrenergic beta. But they are all involved in various aspects of the same system, so it might go toward explaining why some people have POTS, some have NMH, some have both, and some have hypertensive POTS.
This fits my experience. Alpha-1 agonism seems to abolish OI for me, but I still have tachycardia. Beta-blockers take care of tachycardia, but makes OI worse. Perhaps combining alpha-1 agonism (or alpha-2 antagonism) with a beta blocker would perhaps be optimal.
Is there any way to clear the antibodies? Would an antiviral help?
Does anyone happen to know if these auto-antibodies were previously known to science? i.e. had they previously been detected in other research? (I haven't read the full paper.)
From the above :
A while back I wrote about a condition called complex regional pain syndrome - a chronic multi-symptom disorder that follows a relatively trivial peripheral injury with symptoms as follows :
An autoimmune contribution to CRPS now seems likely with similar receptors affected :
I thought CRPS might be quite a good model for ME/CFS :
POTS is a symptom that features in this recent review article on autoimmune diseases.
Thank you very much for that
It would be interesting if something like POTS research leads ME to be finally known to all as an autoimmune disease. I have the POTS due to the ME.
I've got Pots and I recently checked if I had the SLC6a2 snp using 23 and me and livewello and I don't. So.... Am thinking if it's not a genetic issue with the NE transporters it could be antibody driven. I hope they get some answers from the next larger study. Earlier this year they used the Dysautonomia conference in the US to collect blood from pots patients I hope this sample shows a link and treatment options follow soon
Am thinking of trying Anatabine supplement which has been shown to help reduce thyroid antibodies
My brain can't follow anything scientific today but thank you for posting this study and tachycardia was the very first symptom that I got following mono before I had full-blown dysautonomia and ME/CFS.
My 2nd cardiologist said she had seen inappropriate sinus tachy/POTS in female patients around my age (then 42) who had mono/EBV in the prior year. This was the first time I made any connection. She had no idea how to treat it other than trying beta blockers and hoped it would resolve on it's own in six months (which it didn't.)
I am now on a whole cocktail of meds for cardiac/autonomic issues but nothing is working correctly at the moment which is very discouraging.
There are currently treatments like IVIG and plasmapheresis that will reduce the antibodies but I don't think they are permanent. I'm sure now they are looking in the right place solutions will come.
Is this antibody not limitted of effecting pots patient only? From googling i also find other heart issue.
Why does it say betablocker wont work
Anyway it seems its not known to many doctors.
Im worried also what to do then.
Is this the same?
BBC News | Health | Immune system 'causes heart failure
Its published on 1999 though.
But it seems its still vague and no test, treatment available.
Also it says bad things about beta blocker which worries me
Has this already been posted? Dr. David Kem of OU interviewed on Oklahoma News 9:
The OU researchers have "identified a decoy protein to short-circuit those antibodies responsible for the condition”.
Dr. Kem: “This would be a cure, and we hope even an oral cure."
This is a really short clip and worth watching. There is always the question, when you talk about a cure, what are you curing, what caused this? This is talking about a sort of by-pass, or as they say short-circuit--which would be very welcome, but what went wrong that might still need to be fixed after the "short-circuit" treatment?
You can also try a Google Site Search
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