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Autism successfully treated - latent Lyme disease the culprit - energy levels lifted

Discussion in 'Lyme Disease and Co-Infections' started by Bob, Feb 21, 2012.

  1. Bob

    Bob

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    Interesting video about a french doctor who has successfully treated some autistic children with courses of antibiotics.

    http://www.youtube.com/watch?v=yOno_2m_8LY&feature=youtu.be

    Early on in the video, it mentions that Lyme disease bacteria was found to be the problem, but then it doesn't say any more about Lyme disease. Later in the video, the researcher says he doesn't want to talk about the bacteria he has detected. So it's a bit confused, and we need further info. Also, latent infections are mentioned.

    It's interesting that the video mentions autism, Lyme disease, latent infections and low energy levels... All things that have been associated with ME in various ways.


    Here are some quotes from the video:

    "He discovered the culprit of his problems: Lyme Disease due to bacteria transmitted by ticks."

    "The researcher devised a novel method which enables him to detect latent infections in blood of young people with autism"


    Theory: "Bacteria come from the intestinal mucosa which, when inflammation is present, will seep through the very fragile mucosa into the bloodstream, which in turn, produce toxins which can reach the brain."

    I haven't come across any more info about this yet.
  2. natasa778

    natasa778 Senior Member

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    Hi Bob, there is one study where they found levels of bacterial endotoxins in the blood directly correlated severity of autism. (Exactly the same thing found in HIV+ with neurological symptoms)

    Low-grade endotoxemia in patients with severe autism

    http://www.ncbi.nlm.nih.gov/pubmed/20097267
    justy likes this.
  3. Bob

    Bob

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    Thanks natasa. Interesting. I wonder if any research has been done with ME and endotoxins. I don't recall ever having seen any.
  4. natasa778

    natasa778 Senior Member

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    I can only find these two by Maes, both measuring IgA and IgM responses

    Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability
    http://www.ncbi.nlm.nih.gov/pubmed/17007934

    Normalization of leaky gut in chronic fatigue syndrome (CFS) is accompanied by a clinical improvement: effects of age, duration of illness and the translocation of LPS from gram-negative bacteria
    http://www.ncbi.nlm.nih.gov/pubmed/19112401

  5. redo

    redo Senior Member

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    Thanka for posting Bob.
  6. Enid

    Enid Senior Member

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    Good viewing - thanks Bob. And personally all these new discoveries are confirming what I instinctively knew 12 years even before rapid decline about the compromised Gut.

    Autism now infection too! - hooray they can now treat. And remove permanently the pathetics in Psychiatry.
    Athene likes this.
  7. Glynis Steele

    Glynis Steele Senior Member

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    Don't forget de Meirleir's study on CFS patients. He found higher than normal amounts of d-lactic acid producing bacteria in the stool's of CFS patients, compared with healthy controls. This type of bacteria ferment carbohydrate's that have escaped digestion, and produce d-lactic acid as a consequence. D-lactic crosses the BBB and causes neurological changes that are said to be strikingly similar to CFS symptoms eg severe lethargy, cognitive changes such as disorientation, confusion, difficulty in speaking or slurred speech, the feeling of being drunk, blurred vision, weakness and other symptoms. It is a condition usually but only rarely seen in short bowel patients, as they lack the bowel necessary to digest carbohydrates. I wonder whether some kind of carbohydrate malabsorption might produce similar symptoms, and how this would present in patients with a complete bowel, rather than a shortened bowel.

    Here is the de Meirleir study:

    http://www.cfids-cab.org/rc/Sheedy.pdf

    This study is being followed up in Australia, here is a link to the application, with a little info:

    http://sacfs.asn.au/download/Lactic acid study 2008 - Ethics Application.pdf

    As far as autism is concerned, here a a couple of more studies that point at bacterial involvement. Here is the recent Ian Lipkin study which found carbohydrate malabsorption problems in patient's with autism (carb's being fermented by bacteria):

    http://www.plosone.org/article/info...onid=C335DF30F9D78C2F7E964FEDC6C0C4D9.ambra02

    Here is a study which talks about improvements in autistic behaviours when on vancomycin:

    http://www.ncbi.nlm.nih.gov/pubmed/10921511

    This next one talks about difference's in gut flora in autism compared with control's, and says that in this study a higher than normal amount of lactobacilli were found (though I know this is not what is normally seen). Lactobacilli are also d-lactic acid producer's.

    http://www.ncbi.nlm.nih.gov/pubmed/10921511

    This one is about the ketogenic diet used to good effect in autism ie. a carb free diet.

    http://www.ncbi.nlm.nih.gov/pubmed/12693778

    Hope these are of interest. I believe that autism and CFS have a great deal in common, the main one being the fact that the conditions are controlled by psych involvement. Which is why there is a dearth of biomendical research into these conditions.

    Glynis x
  8. natasa778

    natasa778 Senior Member

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    Another thing in common is the biased reporting of research by the media, in that the really good and important research rarely gets a mention. When it is reported, it is always 'balanced' by put-down comments by the dark side (so called experts).
    Athene likes this.
  9. Bob

    Bob

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    Let's hope so Enid!
  10. Bob

    Bob

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    I'd really like to find some more info about this...
    It might only be a subset of Autistic children who benefit from the treatment...
    And we would need to see a proper clinical trial carried out before we can be certain of the results.

    I've just noticed that it says that 4 out of 5 children, who received the antibiotics, saw their symptoms "regress dramatically or disappear altogether."


    Googling for: "autism, philippe raymond, luc montagnier" brings up some further info.
  11. Enid

    Enid Senior Member

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    Yes Bob - it's all now coming together at last from so many disciplines in medicine - chiefly those on the front line caring for patients, open to research findings, free from any UK psycho bias. My own brother (Prof Neurology) took off for the States many years ago with the words "they even believe each other though they know it's wrong". So we watch happily all findings like this and so many more not from the UK but most welcome from overseas. Scrabbling to catch up here.
  12. Glynis Steele

    Glynis Steele Senior Member

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    I also know of a GI in the UK who was doing this type of study, unfortunately, her funding ran out before she got the study published (so she told me). She said it had shown to be an effective treatment, with great improvements made in autistic behaviours. Her name is Dr Sophie Rosseneu. Here is a link to the work she was doing, but it is from another website about autism and gut bacteria, LPS etc. You will need to scroll down to the bottom of the page for the info.

    http://www.microbialinfluence.com/SCD.html
  13. redo

    redo Senior Member

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  14. natasa778

    natasa778 Senior Member

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    Didn't he state in an interview that his research actually does not give credit to homeopathic principles, because the signal they observed in his lab in diluted solutions would be lost each time long before they would reach those dilutions used in homeopathy?
  15. natasa778

    natasa778 Senior Member

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    Antibiotics improving symptoms of autism is nothing new really, but this is the first time it is been talked about on national TV and by high profile figures. And the first time a larger scale study is in the making. Sussed out docs and parents have been using them for a long time. The trick is figuring out which antibiotic for what child. Also which probiotic, which type of digestive enzyme, what type of diet etc. It is all highly individual and I sincerely hope they have found a way of figuring it out relative to design of the study. Having said that the fact that they report 4/5 kids responding makes me think they know how to pick the right antibiotic in most cases :)
    Glynis Steele likes this.
  16. redo

    redo Senior Member

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    That's why I used the word "somewhat". Very many scientists claim that he is linked to it. I am not going to argue that he is a proponent of homeopathy, but it seems like he is somewhat linked to that realm.
  17. Mark

    Mark Acting CEO

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    Wow, thanks for this Natasa! That's an exciting extract for me...

    This joins up very neatly with what I found about weakened tight junctions in relation to itching/neuropathy/allodynia. Research into eczema identified that weakening of the tight junctions, together with another factor, may be the cause of eczema as a whole - in essence, two protective mechanisms are broken in eczema, and the role of tight junctions there has only recently been appreciated; in our case, breakdown of tight junctions are likely to be a factor for many of us.

    The interesting part is that the weakening of the tight junctions can explain both skin and environmental sensitivities, and also gut-related issues - and the relationship between the two. As many of us have observed, regarding the combination of neuropathic pain and gut sensitivity, the two tend to wax and wane together, and both involve protective layers that are compromised by degradation of tight junctions.

    Certain deficiencies (vitamins or enzyme pathways?) may be responsible for the failure of the tight junctions, as well as genetic factors, so there may be multiple reasons why they break down. And for me, there's still the big unanswered question of why they suddenly broke down - I do suspect a pathogen did that because I think I can pinpoint the day it happened...but that's another story...

    But this mention in relation to gut and CFS is the first time I've heard reference to tight junctions regarding either, and strengthens my feeling that the breakdown of these tight junctions is a critical factor for many or maybe for all of us.
  18. Bob

    Bob

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    That's interesting... Did you notice that, in the video, they said that the featured autistic child had itching problems that would exhaust him... The antibiotics relieved the itching along with all his other symptoms.


    I think this is definitely worth investigating further.

    I guess an easy first step would be to think about anti-inflamatory diets, vitamins, minerals and supplements etc...
    And then to investigate pharmaceuticals that might heal or correct the faulty tight junction barriers.

    I have reason to believe that my own ME could possibly be related to gut damage as well... In my case it could be toxin related, pathogen related or both.
  19. redo

    redo Senior Member

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    Does anyone know which antibiotics was used?
  20. Mark

    Mark Acting CEO

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    Didn't have time to watch the video Bob, so thanks for letting me know about the itching factor mentioned! Yet more confirmation of this line of inquiry.

    I looked up more about tight junctions though. A few things that seem significant...

    http://en.wikipedia.org/wiki/Tight_junction

    http://www.nature.com/jid/journal/v127/n11/full/5700865a.html

    So:

    - Tight junctions can be hijacked and disrupted by bacteria and viruses
    - Damage would cause gut issues (through leaky gut) and skin sensitivity issues (through loss of protective barrier).
    - A generalised failure of the tight junctions might cause a partial failure of the blood-brain barrier and let pathogens through that couldn't otherwise reach the brain.

    I do find this quite exciting: the importance of tight junctions is only recently becoming clear, and damage to tight junctions seems like a mechanism that could potentially explain a whole range of issues common in ME/CFS patients - the viral-onset connection, the food and environmental sensitivities, the observed connection between the gut and environmental sensitivities, the apparent neuropathic symptoms ('itching'), the route for pathogens to potentially enter the brain...and going a little further out, a failure of the barrier in the skin that prevents penetration by ions might even have a connection with EMF sensitivities...

    Anybody else find this as exciting as I do? And can anybody find out what one should eat or take as supplements in order to obtain or maintain healthy tight junctions?...

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