I would like to start this new thread so as not to completely hijack KDay's thread on geneticgenie. I also think Autism is absolutely related to CFS/ME, as some of the principles and treatments associated with ASD have worked so very well for me personally.
Kday posted testing SNP's relating to Autism in which I investigated my own results at 23andme. Natasha posted related Interferon and chemokines associated with those with ASD. My investigations were intersting in that my results correlated with the information the both of them presented. I have copied some of their posts here to start the thread. Thank you both for this avenue.
There were 36 total SNP's for females. My results include:
(14) Dominant = 8(+/+), 3(+/-)
(11) Recessive= 4(+/+), 4(+/-)
(11) Additive= 7(+/+), 2(+/-)
Total (+/+) = 19
Total (+/-) = 10
Total (-/-) = 6
NoCall= 1
I went to 23andme, in the Interferon genes or IFNA, I had quite a few results in which NO GENE FOUND was recorded. Whether that is due to deletion as stated in Natasha's quote, or whether 23andme did not test for it, I do not know. None the less, it is interesting for a follow up. The interferon genes are quite specific in 23andme, and only one result is given for each. I do not believe there is a risk allele associated with the INFA and correlating number. But for the chemokines, there are several SNP's listed and of which I am missing information on risk alleles to make an assessment of the SNP's listed.
Natasha, anyone, do you have the risk alleles associated with these SNP's?
There are ten (10) IFNA's listed. Out of those 10, I only have 3. 7 out of the 10 came back as NO GENE FOUND.
Here is a list of what was mentioned in Natasha's post and source quoted. I have included the SNP rs#'s except for those genes that were not found in my DNA profile for IFNA.
NGF= NO GENE FOUND
IFNA10 rs 12555631
IFNA2 rs10120977
IFNA14 NGF
IFNA22 NGF
IFNA4 NGF
IFNA5 NGF
IFNA6 NGF
IFNA7 NGF
IFNA8 rs16938396
IFNA17 NGF
As an aside, this would explain why my projected response to interferon treatment should I contract hepatitis would be compromised as stated in my 23andme profile.
The following is where I need risk alleles... (or is the "gain of copies in the c-c motif they refer to?)
CCL1 rs3136682
CCL1 rs2282692
CCL1 rs159271
CCL1 rs3138032
CCL11 rs1129844
CCL11 rs1860184
CCL11 rs3815341
CCL11 rs4795898
CCL11 rs1019109
CCL13 rs3136677
CCL13 rs159313
CCL2 rs2857657
CCL2 rs4586
CCL2 rs13900
CCL17 rs3091237
CCL17 rs3091321
CCL8 rs3138036
CCL8 rs1133763
Again, thank you for all of this.
LaurieL
Kday posted testing SNP's relating to Autism in which I investigated my own results at 23andme. Natasha posted related Interferon and chemokines associated with those with ASD. My investigations were intersting in that my results correlated with the information the both of them presented. I have copied some of their posts here to start the thread. Thank you both for this avenue.
This is really exciting... A genetic risk test based on 65 SNPs is out for Autism and is currently being tested by the Cleveland Clinic.
It has 65 SNPs, and 23andMe as every single one of them.
How this will help ME/CFS? I have no clue. I'd be very curious if we have high "Autistic" scores as I feel Autism and CFS may have a very similar genetic setup. And if this turns out not to be true, it can help the Autism community.
http://www.arisktest.com/28-understanding-the-report.htm
Full list of SNPs
http://www.integragen.fr/upload/Documents/ARISk Test SNPs.pdf
edit: It turns out their methods (using SNPs) for assessing autism risk are patented, so I don't know how much I could do with it. I am kind of wandering in the gray zone though so I don't really know how patent laws would apply to me.
There were 36 total SNP's for females. My results include:
(14) Dominant = 8(+/+), 3(+/-)
(11) Recessive= 4(+/+), 4(+/-)
(11) Additive= 7(+/+), 2(+/-)
Total (+/+) = 19
Total (+/-) = 10
Total (-/-) = 6
NoCall= 1
kday said:↑
I suspected that ME/CFS would score high on that test because it is my belief that Autism is the same illness. If anyone else wants to post their results, I've automated it and I can send you the link.Remember that on some SNPs you have to change the risk allele letter.
Hi kday, have you seen this on autism risk genes
The five immunological and inflammation gene sets (iCNV-5) again ranked topmost. ...... there is a loss of genomic copies in the interferon alphas (IFNA10, IFNA14, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA8, IFNA17) and gain of copies in the “C-C” motif chemokine ligands (CCL1, CCL11, CCL13, CCL2, CCL7, CCL8) as summarized in Table 1. Several of these chemokines have been found to be overexpressed in inflammatory diseases ... The loss of interferon alpha copies, usually implicated in the response to viral infection and another component of innate immunity, could also account for a dysregulated, secondary or compensatory response of interferons and chemokines. Several of these messengers “…are produced by neurons and glia in the adult brain, and that they can acutely influence synaptic transmission.... The above could be suggestive of a link between in utero infections and brain development in the child. Thus, the genetic background by itself would not be enough via this view to cause a deranged developmental process which would rather only occur in the presence of relevant infections. Interferons are important in the control of viral infections via the induced expression of interferon-stimulated genes [40]. The loss of copy number in the interferon genes suggests a possible reduced expression of such genes when stimulated. Thus, a viral infection would last longer under such a genetic background. Viral infections also lead to the expression of various chemokines in the CNS [41]. Further, chemokines are also involved in brain development [27],[41]. There would therefore be a longer generation of chemokines and other cytokines that could interfere with normal brain development. Further, gain in copy number in chemokines may lead to higher levels of these chemokines and would thus exacerbate the derangement in brain development. ....do these findings match yours and and how do they compare to CFS/ME findings ?
...Natasha
I went to 23andme, in the Interferon genes or IFNA, I had quite a few results in which NO GENE FOUND was recorded. Whether that is due to deletion as stated in Natasha's quote, or whether 23andme did not test for it, I do not know. None the less, it is interesting for a follow up. The interferon genes are quite specific in 23andme, and only one result is given for each. I do not believe there is a risk allele associated with the INFA and correlating number. But for the chemokines, there are several SNP's listed and of which I am missing information on risk alleles to make an assessment of the SNP's listed.
Natasha, anyone, do you have the risk alleles associated with these SNP's?
There are ten (10) IFNA's listed. Out of those 10, I only have 3. 7 out of the 10 came back as NO GENE FOUND.
Here is a list of what was mentioned in Natasha's post and source quoted. I have included the SNP rs#'s except for those genes that were not found in my DNA profile for IFNA.
NGF= NO GENE FOUND
IFNA10 rs 12555631
IFNA2 rs10120977
IFNA14 NGF
IFNA22 NGF
IFNA4 NGF
IFNA5 NGF
IFNA6 NGF
IFNA7 NGF
IFNA8 rs16938396
IFNA17 NGF
As an aside, this would explain why my projected response to interferon treatment should I contract hepatitis would be compromised as stated in my 23andme profile.
The following is where I need risk alleles... (or is the "gain of copies in the c-c motif they refer to?)
CCL1 rs3136682
CCL1 rs2282692
CCL1 rs159271
CCL1 rs3138032
CCL11 rs1129844
CCL11 rs1860184
CCL11 rs3815341
CCL11 rs4795898
CCL11 rs1019109
CCL13 rs3136677
CCL13 rs159313
CCL2 rs2857657
CCL2 rs4586
CCL2 rs13900
CCL17 rs3091237
CCL17 rs3091321
CCL8 rs3138036
CCL8 rs1133763
Again, thank you for all of this.
LaurieL