The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Autism risk genes tied to infectious agents !

Discussion in 'Other Health News and Research' started by natasa778, Dec 5, 2012.

  1. natasa778

    natasa778 Senior Member

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    A genetic autism study that actually makes sense - a long time coming but better late than never. Excuse my modesty ;-) but I have been 'predicting' for a long time that there will be 'autism gene risk' linked to various chemokine receptors. And this is exactly what they found …


    http://www.plosone.org/article/info:doi/10.1371/journal.pone.0048835

    Long and detailed paper, here are highlights:

    Now the really interesting thing is that retroviruses LOVE to insert themselves in host chemokine receptor genes (and I suspect interferon ones?-anyone knows?). Given the recent finding of reactivated HERVs in autism, it would be very interesting in someone now looked into HERVs expression in parents, including germline - wondering if something like this could account for CC and interferon copy number variations.

    It would also tie in with high incidence of auto/immune diseases in autism first degree relatives...
     
  2. anciendaze

    anciendaze Senior Member

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    I have also felt infectious agents were involved. While it would make life simple if we could tie one pathogen like a retrovirus directly to the immune response I'm more and more convinced most of the pathology stems from a misdirected response to secondary infections or common bacteria and viruses normally tolerated. This turned up in an experimental model in mice. (See the review below.)
    http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.1995.tb00072.x/abstract

    The retrovirus, in this view, might trigger the process, but the clinical symptoms would not develop in the absence of other immune challenges. The virus is deliberately misdirecting response to benefit itself. By infecting cells of the immune system it can not merely hide itself from immune defenses, but gain safe replication via clonal expansion of infected cells.
     
  3. natasa778

    natasa778 Senior Member

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    That is exactly my suspicion - retroviral infection or HERV activation (whether in germline or perinatally) lays ground for this 'misdirected response to secondary infections' ?
     
  4. Enid

    Enid Senior Member

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    Thanks natasha - no doubts something viral causing immume collapse (genetics may play a part in predisposition to) Brother ME, cousin FM.
     
  5. natasa778

    natasa778 Senior Member

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    Sciencedaily article on the findings http://www.sciencedaily.com/releases/2012/12/121206203417.htm

     
    alex3619 and merylg like this.
  6. GcMAF Australia

    GcMAF Australia Senior Member

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    bacterial infections and gut inflammation may also play extensive roles.
    It is interesting that GcMAF is being used to modify the immune system and help with autism
     

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