Firestormm
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Infant Neural Sensitivity to Dynamic Eye Gaze Is Associated with Later Emerging Autism
26 January 2012: http://www.cell.com/current-biology/abstract/S0960-9822(11)01469-2
Highlights
Family risk for autism confers subtle differences in brain function in infants
Atypical ERPs in infants when viewing eye gaze data associates with later autism diagnosis
Robust prediction of autism will require an understanding of risk and protective factors
Summary
Autism spectrum disorders (henceforth autism) are diagnosed in around 1% of the population [1]. Familial liability confers risk for a broad spectrum of difficulties including the broader autism phenotype (BAP) [2,3].
There are currently no reliable predictors of autism in infancy, but characteristic behaviors emerge during the second year, enabling diagnosis after this age [4,5]. Because indicators of brain functioning may be sensitive predictors, and atypical eye contact is characteristic of the syndrome [6,7,8,9] and the BAP [10,11], we examined whether neural sensitivity to eye gaze during infancy is associated with later autism outcomes [12,13].
We undertook a prospective longitudinal study of infants with and without familial risk for autism. At 610 months, we recorded infants' event-related potentials (ERPs) in response to viewing faces with eye gaze directed toward versus away from the infant [14].
Longitudinal analyses showed that characteristics of ERP components evoked in response to dynamic eye gaze shifts during infancy were associated with autism diagnosed at 36 months.
ERP responses to eye gaze may help characterize developmental processes that lead to later emerging autism. Findings also elucidate the mechanisms driving the development of the social brain in infancy.
Leftbrainrightbrain on the research: http://leftbrainrightbrain.co.uk/20...aze-is-associated-with-later-emerging-autism/
Leftbrainrightbrain on: Does MMR vaccine travel in time?: http://leftbrainrightbrain.co.uk/2012/01/does-mmr-vaccine-travel-in-time/
26 January 2012: http://www.cell.com/current-biology/abstract/S0960-9822(11)01469-2
Highlights
Family risk for autism confers subtle differences in brain function in infants
Atypical ERPs in infants when viewing eye gaze data associates with later autism diagnosis
Robust prediction of autism will require an understanding of risk and protective factors
Summary
Autism spectrum disorders (henceforth autism) are diagnosed in around 1% of the population [1]. Familial liability confers risk for a broad spectrum of difficulties including the broader autism phenotype (BAP) [2,3].
There are currently no reliable predictors of autism in infancy, but characteristic behaviors emerge during the second year, enabling diagnosis after this age [4,5]. Because indicators of brain functioning may be sensitive predictors, and atypical eye contact is characteristic of the syndrome [6,7,8,9] and the BAP [10,11], we examined whether neural sensitivity to eye gaze during infancy is associated with later autism outcomes [12,13].
We undertook a prospective longitudinal study of infants with and without familial risk for autism. At 610 months, we recorded infants' event-related potentials (ERPs) in response to viewing faces with eye gaze directed toward versus away from the infant [14].
Longitudinal analyses showed that characteristics of ERP components evoked in response to dynamic eye gaze shifts during infancy were associated with autism diagnosed at 36 months.
ERP responses to eye gaze may help characterize developmental processes that lead to later emerging autism. Findings also elucidate the mechanisms driving the development of the social brain in infancy.
Leftbrainrightbrain on the research: http://leftbrainrightbrain.co.uk/20...aze-is-associated-with-later-emerging-autism/
Leftbrainrightbrain on: Does MMR vaccine travel in time?: http://leftbrainrightbrain.co.uk/2012/01/does-mmr-vaccine-travel-in-time/