ATP production is highly dependent on magnesium. Dr.Myhill writes on her website that "AMP can be recycled, but slowly. Interestingly, the enzyme which does this (cyclic AMP) is activated by caffeine! So the perfect pick-me-up for CFS sufferers could be a real black organic coffee with a teaspoon of D-ribose!" Has anyone tried this combo? I think it would send me right through the roof and give me irritated bad energy but I may try it to see what happens.