I think this is relevant to Mehtylation/B12. I've had a small but significant improvement from Mb12/Ab12, Metafolin + some co-factors, (can't tolerate mag. or zinc yet), but keep crashing. I know this is obvious, but it just seems like there is a very limited supply of energy (ATP) available and once I go over the limit... CRASH. And man, do I feel like crap. It almost seems worse than before I started the B12's, etc. because I can do a little more and then it's gone. Rest up, feel like crap, feel pretty down and then things get to the slightly better stage again, until... CRASH. So, is there a way to increase ATP? Found this: How to Boost ATP Levels Overview Adenosine triphosphate, or ATP, is known as the main energy source for cells in the body and aids in various functions like muscle contraction and protein production. While there are no known ways to definitively increase the amount of ATP your body produces, there are supplements that may help boost levels of ATP. Before you take any supplements to increase your ATP levels, talk with your health-care provider. These supplements may not be safe for everyone and can cause adverse interactions with some medications. Step 1 Consume a creatine supplement. According to the University of Maryland Medical Center, the loading dose for exercise performance is typically 5 g creatine, four times a day for one week, and maintenance is 2 to 5 g daily. Creatine is an amino acid naturally made by the body and can be converted into ATP. Step 2 Take 30 to 200 mg daily of coenzymeQ10, or CoQ10, recommends the University of Maryland Medical Center. This compound is involved in the body's production of ATP and helps increase energy levels. Since CoQ10 is fat-soluble, it is best absorbed by the body when taken with food. Taking it at night may also yield better results than taking the supplement in the morning. Step 3 Consume a B-complex vitamin. B vitamins are necessary for the body to produce energy, states the American Cancer Society. Vitamin B-1, or thiamine, is especially necessary for the production of ATP. Taking a B-complex ensures that you are getting all eight B vitamins necessary for optimal bodily functioning. Any comment? Appreciate any input.