Does anyone know of/had experience with a lab which accepts postal samples and does the ATP profile test for mitochondrial dysfunction at a cost that doesn't require taking out a mortgage to pay for it? The background to this is... I was diagnosed with fibromyalgia as a teenager 20+ years ago. I also have a number of long-term chronic conditions, including a rare neurological condition that affects how the body produces cerebrospinal fluid that I was diagnosed with in 2003, but assumed my increasing symptoms of muscle pain, weakness, and fatigue were worsening fibromyalgia symptoms, until I was diagnosed with ME around 18 months ago. The neurologiist said it was due to 'emotional trauma' and suggested the usual graded exercise and CBT. I've been down that route before with my fibromyalgia, and the exercise just made my symptoms worse, and counselling was a waste of time, as the only issue I have is that my worsening health is incredibly frustrating, as I can't do the things I want to do. One of the things the neurologist mentioned in his letter to my GP following the consultation, which he also copied to me, was that mitochondrial disease (not the same as mitochondrial dysfunction) needed to be excluded. He didn't give any clues though as to how I should be tested, where, etc., and after a protracted search my GP and I managed to find an NHS consultant with expertise in this area. It's a few weeks now since I saw the neurologist, and to be honest, the consultation was a waste of time. It was obvious that he'd made his mind up about me even before I saw him. He stressed that he'd requested information from doctors I'd seen previously. It seems that seeing a number of doctors in an effort to get appropriate tests, an accurate diagnosis, and some attempt at a treatment labels you as a hypochondriac, someone who needs counselling, and a waste of time for doctors treating physical ailments, but I'm sure many of you have similar experiences. He started the consultation by saying that he didn't think it was appropriate to test me for mitochondrial disease (even though I have many of the symptoms suggesting it). The testing involves a blood test, muscle biopsy, and genetic tests, and didn't even want to do nerve conduction studies. The excuse he gave for not doing the tests was that I'm on life-long warfarin as I have an inherited clotting disorder. I've had alsorts of things done while on warfarin, or I've temporarily stopped the warfarin and done injections of anticoagulants, and it's not been a problem. I've now self-tested, and self-managed my warfarin dosage for a number of years, and only last week had two toe-nails removed due to ingrowing toe-nails, and it wasn't a problem. At the end of the consultation the neurologist said he thought it was "unfortunate" that the neurologist I saw 18 months ago had mentioned mitochondrial disease, and said he thought "it would be very unlikely to have another rare neurological condition" in a way that suggested I was looking for something to be wrong. His conclusion was that my condition is a "functional disorder" - i.e. psychosomatic. As you can imagine, I wasn't in the best of moods after all that! Normally I get on well with doctors and I'm prepared to give them the benefit of the doubt. I know they're only human, and can make mistakes, and can't know everything. With this one though, from the start he made me feel as though I was a hindrance and what I had to say wasn't relevant. I came away feeling as though I'd hit a brick wall, and wasn't really sure what happens next. While I was trying to find someone with expertise in the area of mitochondrial disease I read Dr Myhill's book on mitochondrial dysfunction, and then of course found out that she's not accepting new patients. I do believe that there is some element of mitochondrial dysfunction in ME though, and I'm now thinking that I need to go down the ATP profile testing route. I had discussed this with my GP prior to seeing the latest neurologist, and she was happy for me to have blood taken at the surgery if I found a lab to do the testing. I've been in touch with Acumen labs, which Dr Myhill mentions, and they only accept referrals from doctors they already deal with. I've also been in touch with Biolab who offer a "CFS/ME Profile" which is £400+ and includes a variety of tests but doesn't include the ATP profile test. From the reading and research I've done, I'm convinced that there's a biomedical basis to ME, most probably mitochondrial, and given that the last neurologist I saw wouldn't do the mitochondrial disease testing, I'm thinking that mitochondrial dysfunction testing is logically the next step. My GP is happy for me to have blood taken at the surgery if I find a lab to do the testing. Does anyone know of/had experience with a lab which accepts postal samples and does the ATP profile test at a cost that doesn't require taking out a mortgage to pay for it?