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Astounding Norwegian research breakthrough with Rituximab can solve CFS mystery!!!

Discussion in 'Rituximab: News and Research' started by urbantravels, Oct 19, 2011.

  1. ramakentesh

    ramakentesh Senior Member

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    Nothing surprises me...

    have you ever looked into abnormalities in folate and b12 metabolism and epigenetic promoter methylation? As in gene silencing through abherant methylation of gene promoters?
  2. Freddd

    Freddd Senior Member

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    A very little. What are you getting at, that in the lack of mb12 and methylfolate, that together control the DNA transcription going on in cell division could be corrupted by inadequate quantities of either or both? Multiple cancers are being investigated as being caused by this mechanism in deficiency, and that this can cause autoimmune disorder via the same broken mechanism? I'm not clear on how this might apply. Can you explain more please?

    Just a thought, consider this as a classic Greek tragedy where the whole situation is caused by a character flaw, in this case of the researchers, unable, because of arrogance to hear anything from anyone outside of their club who all respect and have the same arrogance.
  3. ramakentesh

    ramakentesh Senior Member

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    Most of the work I have seen on folate and B12 has related to abherant enigenetic regulation of transcription of genes. Apparently diets high in one or the other can have effects on the methylation status - that is the attachment of methyl to CpG islands on the promoter regions of genes. these hypermethylated promoters effectively turn of transcription of the particular gene - in cancer where there is reduced transcrption of tumour-supresser genes and perhaps in conditions like POTS where they may be hypermethylation of the norepinephrine transporter gene resulting in loss of transcription and reduced expression of this protein.

    Epigenetics is a pretty new area but they are learning quite quickly what might have effects on this aberrant hypermethylation or in other cases hypomethylation of genes or promoters.

    http://en.wikipedia.org/wiki/Hypermethylation

    QUite often in these texts there is mention of b12 and folate as having potential to alter the normal balance of promoter methylation and transcription:

    Some examples include:

    http://www.ncbi.nlm.nih.gov/pubmed/19755648
    http://www.ncbi.nlm.nih.gov/pubmed/21333513
    http://cebp.aacrjournals.org/content/13/4/511.full
    http://www.rescancer.com/bmc-cancer/6589.html

    Just something I thought you might be interested in. thanks
  4. Tia

    Tia Senior Member

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    Thanks for asking, Liquid. :) Unfortunally they're not treating it at all because the doctor says if they treat with tyreostatics, and the bloodworks (dont know the word for it) goes down, I could go hypo instead of as now; hyper, so they won't treat it. Therefore I have to live with all the symptoms.
  5. Tia

    Tia Senior Member

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    Did you do anything special to get where you ae now or did the body itself fix it? Sry if you already told, I don't have the energy to read it all. :oops:
  6. DaiWelsh

    DaiWelsh

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    I am no expert but my wife has hypothyroidism and that seems odd to me; IIUC hypothyroidism while it causes extreme exhaustion/sluggishness is not life threatening (at least directly) while hyperthyroidism is potentially life threatening. As I say, no expert, but fwiw that is my understanding...
  7. lansbergen

    lansbergen Senior Member

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    I take levamisole. I try not to overdo and when possible I avoid places with high infection pressure.
  8. Tia

    Tia Senior Member

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    Yeah, she's hypo, I'm the opposite: hyper. But my doctor told me that hypo can be lifethreatening because the heart can beat so slow that it eventually stops..something like that, if left untreated.
  9. alex3619

    alex3619 Senior Member

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    fla likes this.
  10. Dolphin

    Dolphin Senior Member

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  11. Vitalic

    Vitalic Senior Member

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    That seemed slightly more emotive than their previous responses. While I enjoyed seeing them stick it to a BSP advocate, at the same time I'm getting flashbacks of Judy Mikovits passionately defending any criticism of the Science paper, and then the patents that have already been declared before adequate replication/validation has been performed, but I suspect that is common practice when potential discoveries are made. I just don't want this to go the same way as XMRV...

    Honestly though, to look at the clinical responses in these patients and put it down to cognitive processes is absurd and exposes how deeply entrenched their psychiatric dogmas are. The most telling feature of this study for me was the two people in the control group who responded positively were the only two who met Oxford/Fukuda but not Canadian consensus criteria, which quite clearly highlights the division that needs to be made between chronic fatigue and ME.
    madietodd likes this.
  12. Snow Leopard

    Snow Leopard Senior Member

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    The reality is that the results of this study don't much matter in the long run. They are now doing a larger study, from what I have seen they are top notch researchers and are taking all of the criticisms on board.

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