• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Association of biomarkers with health-related quality of life and history of stressors in [ME/cfs]

Kyla

Kyla

ᴀɴɴɪᴇ ɢꜱᴀᴍᴩᴇʟ
Messages
721
Location
Canada
http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1010-x
(open access)

Association of biomarkers with health-related quality of life and history of stressors in myalgic encephalomyelitis/chronic fatigue syndrome patients
  • Emmanuel Fenouillet,
  • Aude Vigouroux,
  • Jean Guillaume Steinberg,
  • Alexandre Chagvardieff,
  • Frédérique Retornaz,
  • Regis Guieu and
  • Yves JammesEmail author
Journal of Translational Medicine201614:251
DOI: 10.1186/s12967-016-1010-x

© The Author(s) 2016

Received: 9 June 2016

Accepted: 16 August 2016

Published: 31 August 2016

Abstract
Background
Myalgic encephalomyelitis chronic fatigue syndrome (ME/CFS) is a common debilitating disorder associated with an intense fatigue, a reduced physical activity, and an impaired quality of life. There are no established biological markerof the syndrome. The etiology is unknown and its pathogenesis appears to be multifactorial. Various stressors, including intense physical activity, severe infection, and emotional stress are reported in the medical history of ME/CFS patients which raises the question whether any physiological and biological abnormalities usually found in these patients could be indicative of the etiology and/or the quality-of-life impairment.

Methods
Thirty-six patients and 11 age-matched healthy controls were recruited. The following variables that appear to address common symptoms of ME/CFS were studied here: (1) muscle fatigue during exercise has been investigated by monitoring the compound muscle action potential (M-wave); (2) the excessive oxidative stress response to exercise was measured via two plasma markers (thiobarbituric acid reactive substances: TBARS; reduced ascorbic-acid: RAA); (3) a potential inflammatory component was addressed via expression of CD26 on peripheral blood mononuclear cells; (4) quality-of-life impairment was assessed using the London Handicap Scale (LHS) and the Medical Outcome Study Short Form-36 (SF-36). The medical history of each patient, including the presence of stressors such as intense sports practice, severe acute infection and/or severe emotional stress was documented.

Results
We observed that: (1) there were striking differences between cases and controls with regard to three biological variables: post-exercise M-wave, TBARS variations and CD26-expression at rest; (2) each of these three variables correlated with the other two; (3) abnormalities in the biomarkers associated with health-related quality of life: the LHS score was negatively correlated with the exercise-induced TBARS increase and positively correlated with CD26-expression while the pain component of SF-36 was negatively correlated with CD26-expression; (4) the TBARS increase and the M-wave decrease were the highest, and the CD26-expression level the lowest in patients who had been submitted to infectious stressors.

Conclusion
In ME/CFS patients, severe alterations of the muscle excitability, the redox status, as well as the CD26-expression level are correlated with a marked impairment of the quality-of-life. They are particularly significant when infectious stressors are reported in the medical history.
Click to expand...
 
Biarritz13

Biarritz13

Senior Member
Messages
699
Location
France
Effi said:
@Theodore I was just trying to find out who these researchers are - have never heard of them! Do you have any more info?
Click to expand...

Cheshire said:
Yep, just discovered this French team.
I didn't kown anyone in France was working on this...
Click to expand...

I just know that the Dr. Frederique Retornaz is the leading one in this team, she is an internal doctor. The team is also composed by a doctor in Biochemestry, a GP, a Physiotherapist and others that I am not aware of.

I am surprised by a patient of Dr. Retornaz told me that she was doing some exercice with the Physio...So I thought it was GET or something...
 
Snow Leopard

Snow Leopard

Hibernating
Messages
5,902
Location
South Australia
Keep in mind that this is not the first, but the third time these main findings have been studied (Compound action potential (M-wave) alterations and elevated oxidative stress markers (TBARS))

I don't know why there isn't much discussion of these findings (and the HSP findings that Marco mentioned).
 
You must log in or register to reply here.