Yes, it's quite amazing that there has been so little research on the pronounced sex ratio in this illness - someone coming across the illness for the first time might think it was one of the most striking aspects of this hard to fathom disease. As an alternative to the hysteria hypothesis, could it be down to the immune system? Women generate stronger immune responses than men (the vast majority of autoimmune diseases are much more common in women than men). I gather this difference is immune systems is true for mammals and I other animals too, as testosterone can suppress immune response. The immune system, and particualarly the immune system over-reacting, is often linked to ME/CFS - so if women have stronger immune reactions you might expect more women to get ME. As for gender differences, am I right in thinking that men are even more impressed by Dr Singh than women are? More seriously, it's frustrating that she's not giving much away about the results of her research; it's very professional of her and I think the right thing to do, but there is a hint there could be some incredibly important results coming out of her work.